Calcium diascorbate Property

alpha 

D20 +95.6° (c = 2.4)

Odor

Odorless or almost odorless.

LogP

-2.653 (est)

CAS DataBase Reference

5743-27-1(CAS DataBase Reference)

EPA Substance Registry System

Calcium ascorbate anhydrous (5743-27-1)

Safety

Hazardous Substances Data

5743-27-1(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Calcium diascorbate Chemical Properties,Usage,Production

Description

Calcium diascorbate is a neutral ascorbate, not irritating to the stomach. It can provide about 10% of calcium that is very easily absorbed while supplementing with vitamin C. Calcium diascorbate is anti-oxidative, anti-viral, anti-toxin, anti-allergic, immune-enhancing, and an important factor in the synthesis of collagen, the most important supporting tissue in the body, as well as the still controversial anti-cancer effect.

Uses

Nutritional supplement.

Uses

Calcium Ascorbate is the salt of ascorbic acid which is a white to slightly yellow crystalline powder. It is soluble in water and the ph of a 10% solution is 6.8–7.4. It functions as an antioxidant and preservative. See ascorbic acid.

Indications

Calcium diascorbate is a vitamin C supplement.
1. the treatment of vitamin C deficiency.
2. Provide high levels of vitamin C required by the human immune system to reduce the duration and frequency of viral infections.
3. Meet the extra needs of vitamin C for people who are pregnant, breastfeeding, post-surgery, antibiotic treatment, those with digestive and absorption disorders, and regular smokers.

Mechanism of action

Calcium diascorbate is involved in amino acid metabolism, synthesis of neurotransmitters, collagen and tissue interstitium. It can supply an appropriate amount of vitamin C and calcium which can promote the body's nutrient metabolism and energy production, enhance immune function, improve vascular adaptability, improve the elasticity and tension of skin, blood vessels and other tissues. In vivo, ascorbic acid and dehydroascorbic acid form a reversible redox system that plays an important role in biological oxidation and reduction processes and cellular respiration.

Pharmacology

After oral administration, Calcium diascorbate is rapidly absorbed by the gastrointestinal tract and decomposed into vitamin C and calcium ions. Vitamin C is distributed in various tissues and organs in the body, with the highest concentration in glandular tissue and the least in muscle fat; the concentration in white blood cells and platelets is higher than that in red blood cells and plasma. Part of vitamin C is metabolized in the body into oxalic acid and chemicalbook carbon dioxide for excretion, and part of it is excreted in the urine in the reduced or dehydrogenated form. If the plasma concentration of vitamin C exceeds the renal threshold (about 1.4 mg%), and the administration is continued, most of the vitamin C is excreted in the urine. If the plasma content is less than 1.4mg%, the vitamin C taken is taken up by tissue cells and rarely appears in the urine.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Synthesis

Add 44g VC and water (1mL/g) to a three-necked bottle equipped with an electric stirrer, slowly add a certain amount of calcium carbonate (VC:CaCO3=1:0.525) with stirring at 50°C and be covered with CO2. After 100min of reaction, suction filtration, transfer the filtrate into a three-necked flask, add a large amount of methanol at room temperature, slowly crystallize with alcohol, continue to cool down after adding, suction filtration, wash with methanol, and vacuum dry to obtain Calcium diascorbate.