tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate

Product Name: tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate
CAS No.: 288251-87-6
Chemical Name: tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate
Synonyms: tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-(2-cyano-4-nitrophenyl)-, 1,1-dimethylethyl ester
CBNumber: CB42661340
Molecular Formula: C16H20N4O4
Formula Weight: 332.35
MOL File: 288251-87-6.mol

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tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate Property

Boiling point:: 499.2±45.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 0.02±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB143338
Product name: tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate
Packaging: 100mg
Price: $56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143338
Product name: tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate
Packaging: 250mg
Price: $112.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143338
Product name: tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate
Packaging: 500mg
Price: $195
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143338
Product name: tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate
Packaging: 1g
Price: $340
Updated: 2021/12/16

AK Scientific

Product number: Z4553
Product name: tert-Butyl4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate
Packaging: 1g
Price: $361
Updated: 2021/12/16

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tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

17417-09-3

57260-71-6

288251-87-6

Step a: Synthesis of tert-butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate; To a solution of DMF (50 mL) containing N-BOC-piperazine (5.61 g, 30.1 mmol) and potassium carbonate (4.2 g, 30.1 mmol) was slowly added 2-fluoro-5-nitrobenzonitrile (5.0 g, 30.1 mmol). The reaction mixture was stirred at 50°C for 2 hours. Upon completion of the reaction, the mixture was poured into water, the resulting precipitate was collected by filtration and washed with water. After drying under high vacuum, tert-butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate (8.66 g, 86.6% yield) was obtained as a yellow solid, which could be used in the subsequent reaction without further purification.LC/MS analysis: retention time 6.22 min, detected as m/z 274.2 [M+H+CH3CN-Boc]+.

References

[1] Patent: US2009/99199, 2009, A1. Location in patent: Page/Page column 17-18
[2] Patent: WO2008/141976, 2008, A1. Location in patent: Page/Page column 49
[3] Patent: WO2009/79597, 2009, A1. Location in patent: Page/Page column 62-63; 152
[4] Patent: WO2005/54238, 2005, A1. Location in patent: Page/Page column 92
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5552 - 5556

tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate Suppliers

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288251-87-6, tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylateRelated Search:

tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate

1-Piperazinecarboxylic acid, 4-(2-cyano-4-nitrophenyl)-, 1,1-dimethylethyl ester

288251-87-6