(R)-1-tert-Butyl 2-Methyl aziridine-1,2-dicarboxylate
- Product Name
- (R)-1-tert-Butyl 2-Methyl aziridine-1,2-dicarboxylate
- CAS No.
- 1239355-46-4
- Chemical Name
- (R)-1-tert-Butyl 2-Methyl aziridine-1,2-dicarboxylate
- Synonyms
- Boc-D-Azi-OMe;Reaxys ID: 20582563;Methyl (R)-1-Boc-aziridine-2-carboxylate;(R)-N-Boc-Aziridine-2-carboxylic acid methyl ester;(R)-1-tert-Buty1 2-Methyl aziridine-1.2-dicarboxylate;(R)-1-tert-Butyl 2-Methyl aziridine-1,2-dicarboxylate;1-tert-butyl 2-methyl (2R)-aziridine-1,2-dicarboxylate;1,2-Aziridinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-methyl ester, (2R)-;(R)-Methyl 1-n- (R)-Methyl 1-n-boc-aziridine-2-carboxylateboc-aziridine-2-carboxylate
- CBNumber
- CB42661724
- Molecular Formula
- C9H15NO4
- Formula Weight
- 201.22
- MOL File
- 1239355-46-4.mol
(R)-1-tert-Butyl 2-Methyl aziridine-1,2-dicarboxylate Property
- Boiling point:
- 248.7±33.0 °C(Predicted)
- Density
- 1.189±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- -5.60±0.40(Predicted)
- color
- Colourless
- optical activity
- Consistent with structure
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8154DC
- Product name
- (R)-1-Tert-Butyl2-methylaziridine-1,2-dicarboxylate
- Packaging
- 250mg
- Price
- $268
- Updated
- 2021/12/16
- Product number
- M17905
- Product name
- 1-tert-butyl2-methyl(2R)-aziridine-1,2-dicarboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- M17905
- Product name
- 1-tert-butyl2-methyl(2R)-aziridine-1,2-dicarboxylate
- Purity
- 97.0%
- Packaging
- 5g
- Price
- $980
- Updated
- 2021/12/16
- Product number
- M17905
- Product name
- 1-tert-butyl2-methyl(2R)-aziridine-1,2-dicarboxylate
- Purity
- 97.0%
- Packaging
- 10g
- Price
- $1640
- Updated
- 2021/12/16
- Product number
- 64376
- Product name
- (R)-METHYL1-N-BOC-AZIRIDINE-2-CARBOXYLATE
- Purity
- 97%
- Packaging
- 5/ G
- Price
- $1081
- Updated
- 2021/12/16
(R)-1-tert-Butyl 2-Methyl aziridine-1,2-dicarboxylate Chemical Properties,Usage,Production
Uses
(R)-Methyl 1-N-Boc-aziridine-2-carboxylate is a reactant useful for the preparation of glucosylceramide synthase inhibitors.
Synthesis
24424-99-5
160233-42-1
1239355-46-4
The general procedure for the synthesis of 1-tert-butyl (R)-2-methylaziridine-1,2-dicarboxylate from di-tert-butyl dicarbonate and methyl (R)-1-tritylaziridine-2-carboxylate was as follows: firstly, cyclopropylamine (1400 g, 4.08 mol, 1 eq.), a cyclopropyl amine (1400 g, 4.08 mol, 1 eq.), a 2-methyl-aziridine-2-carboxylic acid, was added to dichloromethane (7 L), which had been pre-cooled to 7 °C. The reaction mixture was then slowly stirred and cooled to -10 °C with stirring. Subsequently, trifluoroacetic acid (700 g, 6.14 mol, 1.5 eq.) was slowly added and the reaction mixture was cooled with stirring to -10°C. Next, triethylamine (1600 g, 15.84 mol, 3.88 eq.) was slowly added to adjust the pH to about 8. Under these conditions, BOC anhydride (900 g, 4.13 mol, 1.01 eq.) was slowly added dropwise. The reaction temperature was maintained between -10°C and 0°C and the pH was maintained at pH = 8. Upon completion of the reaction, water was added to quench the reaction, followed by washing with hydrochloric acid. The organic phase was dried with anhydrous sodium sulfate and then the solvent was removed by rotary evaporation to give a colorless oily product, 1-tert-butoxycarbonyl(R)-2-hydroxymethyl-cyclopropylamine, in 70% yield.
References
[1] Patent: CN105237560, 2016, A. Location in patent: Paragraph 0072; 0073
(R)-1-tert-Butyl 2-Methyl aziridine-1,2-dicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-1-tert-Butyl 2-Methyl aziridine-1,2-dicarboxylate manufacturers
- Product
- (R)-1-tert-Butyl 2-Methyl aziridine-1,2-dicarboxylate 1239355-46-4
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-26