4-AMinobicyclo[2.2.2]octan-1-ol hydrochloride
- Product Name
- 4-AMinobicyclo[2.2.2]octan-1-ol hydrochloride
- CAS No.
- 1403864-74-3
- Chemical Name
- 4-AMinobicyclo[2.2.2]octan-1-ol hydrochloride
- Synonyms
- 4-AMINOBICYCLO[2.2.2]OCTAN-1-OL HCL;4-AMinobicyclo[2.2.2]octan-1-ol hydrochloride;Bicyclo[2.2.2]octan-1-ol, 4-amino-, hydrochloride (1:1)
- CBNumber
- CB42661759
- Molecular Formula
- C8H16ClNO
- Formula Weight
- 177.67
- MOL File
- 1403864-74-3.mol
4-AMinobicyclo[2.2.2]octan-1-ol hydrochloride Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CHM0389832
- Product name
- 4-AMINOBICYCLO[2.2.2]OCTAN-1-OL HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.24
- Updated
- 2021/12/16
- Product number
- A100144
- Product name
- 4-Aminobicyclo[2.2.2]octan-1-olhydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $600
- Updated
- 2021/12/16
- Product number
- CD13023127
- Product name
- 4-Aminobicyclo[2.2.2]octan-1-olhydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $1088
- Updated
- 2021/12/16
- Product number
- CM243908
- Product name
- 4-Aminobicyclo[2.2.2]octan-1-olhydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $1403
- Updated
- 2021/12/16
- Product number
- A100144
- Product name
- 4-Aminobicyclo[2.2.2]octan-1-olhydrochloride
- Purity
- 97%
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
4-AMinobicyclo[2.2.2]octan-1-ol hydrochloride Chemical Properties,Usage,Production
Synthesis
1403864-73-2
1403864-74-3
To a solution of benzyl 4-hydroxybicyclo[2.2.2]octan-1-yl carbamate (14.8 g, 53 mmol) in methanol (200 mL) was added palladium carbon catalyst (0.5 g, 10% w/w). The reaction mixture was placed at 50 °C and the reaction was stirred overnight in a hydrogen atmosphere (50 Psi). Upon completion of the reaction, the catalyst was filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was dissolved in a methanol solution of hydrochloric acid (10% v/v, 50 mL) and stirred at room temperature for 2 hours. Subsequently, the reaction mixture was concentrated again under reduced pressure, tetrahydrofuran (THF, 20 mL) was added and stirred for 1 h at room temperature. The precipitated solid was collected by filtration and dried to give 4-aminodicyclo[2.2.2]octan-1-ol hydrochloride (6.7 g, 36 mmol, 70% yield). The product was characterized by 1H NMR (DMSO-d6): δ 8.00 (s, 3H), 4.48 (br s, 1H), 1.76-1.80 (m, 6H), 1.58-1.61 (m, 6H). The mass spectrum (ESI) showed m/z 142.1 [M+H]+.
References
[1] Patent: WO2012/145569, 2012, A1. Location in patent: Page/Page column 137
4-AMinobicyclo[2.2.2]octan-1-ol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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