2-Chloro-5-cyanobenzoic acid

Product Name: 2-Chloro-5-cyanobenzoic acid
CAS No.: 89891-83-8
Chemical Name: 2-Chloro-5-cyanobenzoic acid
Synonyms: 2-Chloro-5-cyanobenzoic acid;Benzoic acid, 2-chloro-5-cyano-;2-chloro-5-cyano-benzoic acid 97%
CBNumber: CB42662019
Molecular Formula: C8H4ClNO2
Formula Weight: 181.58
MOL File: 89891-83-8.mol

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2-Chloro-5-cyanobenzoic acid Property

Melting point:: 178 °C
Boiling point:: 334.7±27.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 2.31±0.25(Predicted)

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Safety

HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C611515
Product name: 2-chloro-5-cyanobenzoicacid
Packaging: 50mg
Price: $155
Updated: 2021/12/16

TRC

Product number: C611515
Product name: 2-chloro-5-cyanobenzoicacid
Packaging: 100mg
Price: $240
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0360989
Product name: 2-CHLORO-5-CYANOBENZOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $497.61
Updated: 2021/12/16

AK Scientific

Product number: 6138BB
Product name: 2-Chloro-5-cyanobenzoicacid
Packaging: 10g
Price: $3781
Updated: 2021/12/16

Ambeed

Product number: A156198
Product name: 2-Chloro-5-cyanobenzoicacid
Purity: 95%
Packaging: 50mg
Price: $95
Updated: 2021/12/16

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2-Chloro-5-cyanobenzoic acid Chemical Properties,Usage,Production

Synthesis

773837-37-9

89-54-3

89891-83-8

An aqueous solution (10 mL) of NaNO2 (2.21 g, 32 mmol) was slowly added to an aqueous solution (40 mL) of 5-amino-2-chlorobenzoic acid (5.0 g, 29.14 mmol) at 0 °C, followed by the addition of concentrated HCl (10 mL). The reaction mixture was kept at -5 °C and stirring was continued for 1 hour. The resulting diazonium salt solution was added dropwise to a pre-prepared solution of potassium copper tetracyanide [prepared from an aqueous solution of KCN (10 g, 15.38 mmol) (18 mL) with an aqueous solution of Cu (7 g, 43.8 mmol) (12 mL) stirred for 1 h at 50 °C]. Upon completion of the reaction, the reaction mixture was acidified with 1.5 N HCl solution, followed by extraction of the target product with EtOAc. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel 60-120 mesh, eluent 1-2% MeOH in CHCl3 solution) to afford 2-chloro-5-cyanobenzoic acid (1.8 g, 34% yield).1H NMR (400 MHz, DMSO-d6) δ 13.92 (br s, 1H), 8.24 (d, J = 2.1 Hz, 1H), 8.02- 7.99 (dd, J = 8.4 Hz, 2.1 Hz, 1H), 7.80-7.78 (d, J = 8.2 Hz, 1H).MS (ESI) m/z: calculated value for C8H4ClNO2: 180.99; measured value: 179.6 (M-H)-.

References

[1] Patent: EP2533783, 2015, B1. Location in patent: Paragraph 0875-0876

2-Chloro-5-cyanobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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89891-83-8, 2-Chloro-5-cyanobenzoic acidRelated Search:

2-Chloro-5-cyanobenzoic acid

2-chloro-5-cyano-benzoic acid 97%

Benzoic acid, 2-chloro-5-cyano-

89891-83-8