ChemicalBook > CAS DataBase List > AMD 070 hydrochloride

AMD 070 hydrochloride

Product Name: AMD 070 hydrochloride
CAS No.: 880549-30-4
Chemical Name: AMD 070 hydrochloride
Synonyms: AMD-070 HCl;Mavorixafor HCl;AMD070 hydrochloride;AMD 070 hydrochloride;AMD-11070 HYDROCHLORIDE;AMD-070 (hydrochloride);AMD-070 (HCl 75%(w/w%));Mavorixafor (AMD-070) triHCl;AMD 070 Hydrochloride - Bio-X ?;AMD-070 hydrochloride(Mavorixafor)
CBNumber: CB42666587
Molecular Formula: C21H28ClN5
Formula Weight: 385.94
MOL File: 880549-30-4.mol

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AMD 070 hydrochloride Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3266
Product name: AMD070 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $71.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3266
Product name: AMD070 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $360
Updated: 2025/07/31

TRC

Product number: B202975
Product name: N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamineMonohydrochloride
Packaging: 1mg
Price: $110
Updated: 2021/12/16

ApexBio Technology

Product number: A3174
Product name: AMD-070hydrochloride
Packaging: 5mg
Price: $140
Updated: 2021/12/16

ApexBio Technology

Product number: A3174
Product name: AMD-070hydrochloride
Packaging: 10mg
Price: $250
Updated: 2021/12/16

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AMD 070 hydrochloride Chemical Properties,Usage,Production

Uses

N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine Monohydrochloride is a potent and selective antagonist of CXCR4. It is also an inhibitor of X4-tropic HIV virus.

Biological Activity

AMD070 (AMD11070) is an orally active, reversible and selective CXCR4 (CD184, fusin) antagonist (IC50 = 13 nM against 100 pM 125I-SDF-1α for binding human CD+/CXCR4+ CEM-CCRF cells) th at inhibits HIV-1 replication in cultures (IC50/host cells = 2 nM/MT-4 and 26 nM/PBMCs; T-tropic HIV-1NL4.3 strain) with no host cytotoxicity even at concentrations above 23 μM.

in vivo

Mavorixafor (2 mg/kg; po; once a day; for 49 days) hydrochloride significantly inhibits the lung metastasis of B88 SDF 1 cells in nude mice^[2].

Animal Model:	BALB/c nude mice (8 weeks of age) injected with B88-SDF-1 cells^[2]
Dosage:	2 mg/kg
Administration:	Oral administration; once a day; for 49 days
Result:	A significant reduction in the number of metastatic lung nodules was observed in the mice.

IC 50

¹²⁵I-CXCL12-CXCR4: 13 nM (IC₅₀); HIV-1 (NL4.3 strain): 1 nM (IC₅₀, In MT-4 cells); HIV-1 (NL4.3 strain): 9 nM (IC₅₀, In PBMCs); HIV-1 (NL4.3 strain): 3 nM (IC90, In MT-4 cells); HIV-1 (NL4.3 strain): 26 nM (IC90, In PBMCs)

AMD 070 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AMD 070 hydrochloride manufacturers

Honest Joy Holdings Limited

Product: AMD-070 hydrochloride 880549-30-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-01-13

880549-30-4, AMD 070 hydrochlorideRelated Search:

AMD 070 hydrochloride

AMD-070 (hydrochloride)

AMD070 HYDROCHLORIDE; AMD 070 HYDROCHLORIDE

AMD070 hydrochloride

AMD-070 (HCl 75%(w/w%))

N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine monohydrochloride

AMD-070 HCl

N1-(1H-Benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine hydrochloride

AMD-11070 HYDROCHLORIDE

AMD-070 hydrochloride(Mavorixafor)

Mavorixafor (AMD-070) triHCl

Mavorixafor HCl

(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine hydrochloride

AMD-070 hydrochloride, 10 mM in DMSO

AMD 070 Hydrochloride - Bio-X ?

AMD-070 hydrochloride (AMD-11070 hydrochloride)

880549-30-4

C21H27N5HCl

C21H30Cl3N5