CX 6258 hydrochloride hydrate

Product Name: CX 6258 hydrochloride hydrate
CAS No.: 1353858-99-7
Chemical Name: CX 6258 hydrochloride hydrate
Synonyms: CX-6258 HCl hydrate;CX6258 hydrochloride hydrate;CX 6258 hydrochloride hydrate;CX-6258 (hydrochloride hydrate);CX-6258 hydrochloride hydrate (CX6258 hydrochloride hydrate);(E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one hydrochloride hydrate;(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one hydrochloride hydrate (1:1:1)
CBNumber: CB42666613
Molecular Formula: C26H27Cl2N3O4
Formula Weight: 516.42
MOL File: 1353858-99-7.mol

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CX 6258 hydrochloride hydrate Property

storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (48.41 mM; Need ultrasonic)
form: Powder
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1530
Product name: CX-6258(hydrochloridehydrate)
Purity: 99.55%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-1530
Product name: CX-6258(hydrochloridehydrate)
Purity: 99.55%
Packaging: 10mg
Price: $192
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611727
Product name: CX-6258 hydrochloride hydrate
Packaging: 10mg
Price: $345.1
Updated: 2021/12/16

ChemScene

Product number: CS-1530
Product name: CX-6258(hydrochloridehydrate)
Purity: 99.55%
Packaging: 50mg
Price: $540
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611727
Product name: CX-6258 hydrochloride hydrate
Packaging: 50mg
Price: $555.9
Updated: 2021/12/16

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CX 6258 hydrochloride hydrate Chemical Properties,Usage,Production

Uses

CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively[1].

in vivo

CX-6258 (50-100 mg/kg; p.o; daily; over a period of 21 days) exhibits robust in vivo efficacy in two Pim kinases driven tumor models^[1].

Animal Model:	Nude mice, MV-4-11 xenograft models^[1]
Dosage:	50 mg/kg, 100 mg/kg.
Administration:	Oral administration; once daily; over a period of 21 days.
Result:	Exhibited dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI.

References

[1] Mustapha Haddach, Jerome Michaux, Michael K, Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med. Chem. Lett., 2012, 3 (2), pp 135-139
[2] Padmanabhan A, Gosc EB, Bieberich CJ. Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells. J Cell Biochem. 2013 May;114(5):1050-7. DOI:10.1002/jcb.24444

CX 6258 hydrochloride hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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CX 6258 hydrochloride hydrate Suppliers

China 23 United States 7 Global 30

AdooQ BioScience, LLC

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