ChemicalBook > CAS DataBase List > LY-2795050

LY-2795050

Product Name: LY-2795050
CAS No.: 1346133-08-1
Chemical Name: LY-2795050
Synonyms: LY2795050;LY-2795050;LY 2795050;LY 2795050; LY-2795050;LY2795050, 10 mM in DMSO;LY2795050;LY 2795050;LY-2795050;1346133-08-1;(S)-3-chloro-4-(4-((2-(pyridin-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide;3-chloro-4-[4-[ [ (2S)-2-(3-pyridyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide;3-chloro-4-(4-{[(2S)-2-(pyridin-3-yl)pyrrolidin-1-yl]methyl}phenoxy)benzamide;Benzamide, 3-chloro-4-[4-[[(2S)-2-(3-pyridinyl)-1-pyrrolidinyl]methyl]phenoxy]-
CBNumber: CB42666653
Molecular Formula: C23H22ClN3O2
Formula Weight: 407.89
MOL File: 1346133-08-1.mol

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LY-2795050 Property

Boiling point:: 532.4±50.0 °C(Predicted)
Density: 1.287±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (122.58 mM; Need ultrasonic)
form: Powder
pka: 15.57±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1519
Product name: LY2795050
Purity: 98.12%
Packaging: 5mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-1519
Product name: LY2795050
Purity: 98.12%
Packaging: 10mg
Price: $384
Updated: 2021/12/16

ChemScene

Product number: CS-1519
Product name: LY2795050
Purity: 98.12%
Packaging: 50mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-1519
Product name: LY2795050
Purity: 98.12%
Packaging: 100mg
Price: $1680
Updated: 2021/12/16

DC Chemicals

Product number: DC10815
Product name: LY2795050
Purity: >98%
Packaging: 1g
Price: $2600
Updated: 2021/12/16

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LY-2795050 Chemical Properties,Usage,Production

Uses

LY2795050 is a short-acting selective κ(kappa)-opioid receptor (KOR) antagonist. LY2795050 has high affinity for the KOR with Ki value of 0.72 nM. LY2795050 can be used for the research of central nervous system dysfunction[1][2].

in vivo

LY2795050 (i.p., 0.032-0.1mg/kg, 30 min) prevents dose-dependent grooming deficits produced by U50,488 in male and female mice^[2].
LY2795050 (i.p., 0.032-0.1mg/kg, 0-150 min) has sexual dimorphism in some behavioral effects^[2].

Animal Model:	C57BL/6J mice^[2] (gonadally intact, adult, male and female)
Dosage:	0.032-0.1 mg/kg
Administration:	i.p., 0.032-0.1mg/kg, 30 min
Result:	Could dose-dependently prevent the self-grooming deficits caused by U50,488 with a 30-min pre-treatment. Not effected in blocking the effects of U50,488 with smaller dose (0.032mg/kg) in either males or females. Decreased immobility in the FST in males at a dose of 0.1mg/kg, but not in females, up to a dose of 0.32mg/kg. Prevented and also reversed (at 0.32mg/kg) the locomotor-depressant effects of U50,488 (10mg/kg), in males and females.

References

[1] Ming-Qiang Zheng, et al. Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging. J Nucl Med DOI:10.2967/jnumed.112.109512
[2] Eduardo R Butelman, et al. Profile of a short-acting κ-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: sex comparison in mice. J Psychopharmacol. 2021 May;35(5):579-590. DOI:10.1177/0269881121996883

LY-2795050 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY-2795050 Suppliers

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1346133-08-1, LY-2795050Related Search:

3-chloro-4-[4-[ [ (2S)-2-(3-pyridyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide

LY 2795050

LY2795050

LY-2795050

(S)-3-chloro-4-(4-((2-(pyridin-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide

LY2795050;LY 2795050;LY-2795050;1346133-08-1

LY 2795050; LY-2795050

Benzamide, 3-chloro-4-[4-[[(2S)-2-(3-pyridinyl)-1-pyrrolidinyl]methyl]phenoxy]-

LY2795050,Inhibitor,central nervous system dysfunction,sex differences,inhibit,Opioid Receptor,κκ-receptor,LY-2795050,LY 2795050

3-chloro-4-(4-{[(2S)-2-(pyridin-3-yl)pyrrolidin-1-yl]methyl}phenoxy)benzamide

LY2795050, 10 mM in DMSO

1346133-08-1