UPF 648

Product Name: UPF 648
CAS No.: 213400-34-1
Chemical Name: UPF 648
Synonyms: DBCC;UPF648;UPF 648;UPF648,UPF 648;(1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 2-(3,4-dichlorobenzoyl)-, (1S,2S)-
CBNumber: CB42667175
Molecular Formula: C11H8Cl2O3
Formula Weight: 259.09
MOL File: 213400-34-1.mol

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UPF 648 Property

Boiling point:: 461.3±45.0 °C(Predicted)
Density: 1.556±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
pka: 3.89±0.11(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4926
Product name: UPF648
Purity: ≥98%(HPLC)
Packaging: 10
Price: $325
Updated: 2021/12/16

TRC

Product number: U800080
Product name: UPF648
Packaging: 10mg
Price: $285
Updated: 2021/12/16

Axon Medchem

Product number: Axon2118
Product name: UPF648
Purity: 99%
Packaging: 2mg
Price: $115.5
Updated: 2021/12/16

Crysdot

Product number: CD31002677
Product name: UPF-648
Purity: 98+%
Packaging: 5mg
Price: $243
Updated: 2021/12/16

Crysdot

Product number: CD31002677
Product name: UPF-648
Purity: 98+%
Packaging: 10mg
Price: $347
Updated: 2021/12/16

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UPF 648 Chemical Properties,Usage,Production

Uses

UPF-648 is a kynurenine 3-monooxygenase (KMO) inhibitor. KMO is a key enzyme that is part of the kynurenine pathway, which is a metabolic pathway that utilizes tryptophan to produce nicotinamide adenine dinucleotide (NAD+). KMO is a potential therapeutic target for treating neurodegenerative and psychiatric disorders.

Biological Activity

UPF-648 is a potent, active site-targeting kynurenine 3-monooxygenase (KMO; kynurenine 3-hydroxylase) inhibitor (IC50 = 20 nM) th at prevents productive binding of the substrate L-kynurenine by perturbing the local active-site structure. UPF-648 protects against neurodegeneration in a murine (30 mg/kg, i.p.) and a Drosophila (100 μM in maize media) model of Huntingtonμs disease by shifting kynurenine pathway metabolism towards enhanced neuroprotective kynurenic acid (KYNA) formation and away from the free radicals generator 3-hydroxykynurenine (3-HK) and the excitotoxic quinolinic acid (QUIN).

storage

Store at +4°C

UPF 648 Preparation Products And Raw materials

Raw materials

Preparation Products

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UPF 648 Suppliers

CHINA 26 United Kingdom 1 United States 9 Global 36

MedChemexpress LLC

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SPIRO PHARMA

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Shanghai EFE Biological Technology Co., Ltd.

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Musechem

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Absin Bioscience Inc.

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Shanghai hongqu biomedical technology co. LTD

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Energy Chemical

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Jinan Jiuli Biotechnology Co. , Ltd.

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213400-34-1, UPF 648Related Search:

DBCC

UPF 648

UPF648

(1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid

Cyclopropanecarboxylic acid, 2-(3,4-dichlorobenzoyl)-, (1S,2S)-

UPF648,UPF 648

213400-34-1