ChemicalBook > CAS DataBase List > UPF 648

UPF 648

Product Name
UPF 648
CAS No.
213400-34-1
Chemical Name
UPF 648
Synonyms
DBCC;UPF648;UPF 648;UPF648,UPF 648;(1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 2-(3,4-dichlorobenzoyl)-, (1S,2S)-
CBNumber
CB42667175
Molecular Formula
C11H8Cl2O3
Formula Weight
259.09
MOL File
213400-34-1.mol
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UPF 648 Property

Boiling point:
461.3±45.0 °C(Predicted)
Density 
1.556±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
pka
3.89±0.11(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4926
Product name
UPF648
Purity
≥98%(HPLC)
Packaging
10
Price
$325
Updated
2021/12/16
TRC
Product number
U800080
Product name
UPF648
Packaging
10mg
Price
$285
Updated
2021/12/16
Axon Medchem
Product number
Axon2118
Product name
UPF648
Purity
99%
Packaging
2mg
Price
$115.5
Updated
2021/12/16
Crysdot
Product number
CD31002677
Product name
UPF-648
Purity
98+%
Packaging
5mg
Price
$243
Updated
2021/12/16
Crysdot
Product number
CD31002677
Product name
UPF-648
Purity
98+%
Packaging
10mg
Price
$347
Updated
2021/12/16
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UPF 648 Chemical Properties,Usage,Production

Uses

UPF-648 is a kynurenine 3-monooxygenase (KMO) inhibitor. KMO is a key enzyme that is part of the kynurenine pathway, which is a metabolic pathway that utilizes tryptophan to produce nicotinamide adenine dinucleotide (NAD+). KMO is a potential therapeutic target for treating neurodegenerative and psychiatric disorders.

Biological Activity

UPF-648 is a potent, active site-targeting kynurenine 3-monooxygenase (KMO; kynurenine 3-hydroxylase) inhibitor (IC50 = 20 nM) th at prevents productive binding of the substrate L-kynurenine by perturbing the local active-site structure. UPF-648 protects against neurodegeneration in a murine (30 mg/kg, i.p.) and a Drosophila (100 μM in maize media) model of Huntingtonμs disease by shifting kynurenine pathway metabolism towards enhanced neuroprotective kynurenic acid (KYNA) formation and away from the free radicals generator 3-hydroxykynurenine (3-HK) and the excitotoxic quinolinic acid (QUIN).

in vivo

Applying an identical experimental design, separate rats were used to study the effect of KMO inhibition on the de novo synthesis of KP metabolites in the lesioned striatum. These animals were bilaterally injected with 0.1 mM UPF 648 and 3H-kynurenine in PBS. 0.1 mM UPF 648 significantly reduced the neosynthesis of 3-HK and QUIN in the lesioned striatum (by 77 % and 66%, respectively) and moderately (27%) but significantly increased the de novo formation of KYNA[1].
Administered to pregnant rats or mice on the last day of gestation, UPF 648 (50 mg/kg, i.p.) produced qualitatively similar changes (i.e., large increases in kynurenine and KYNA and reductions in 3-HK and QUIN) in the brain and liver of the offspring. Rat pups delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia showed further enhanced brain KYNA levels[2].
UPF 648, has an IC50 of 20 nM and provides protection against intrastriatal QUIN injections in kynurenine aminotransferase (KAT II) deficient mice. UPF 648 treatment also shifts KP metabolism towards enhanced neuroprotective KYNA formation[3].

storage

Store at +4°C

UPF 648 Preparation Products And Raw materials

Raw materials

Preparation Products

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UPF 648 Suppliers

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213400-34-1, UPF 648Related Search:


  • DBCC
  • UPF 648
  • UPF648
  • (1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid
  • Cyclopropanecarboxylic acid, 2-(3,4-dichlorobenzoyl)-, (1S,2S)-
  • UPF648,UPF 648
  • 213400-34-1