HMN 176

Product Name: HMN 176
CAS No.: 173529-10-7
Chemical Name: HMN 176
Synonyms: HMN-176;HMN 176;CS-2239;HMN-176 ，S5807;HMN 176; HMN176;HMN-176, 10 mM in DMSO;(E)-4-(2-((4-Methoxyphenyl)sulfonamido)styryl)pyridine 1-oxide;Polo-like Kinase (PLK),HMN-176,HMN176,HMN 176,Inhibitor,inhibit;4-methoxy-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-benzenesulfonamide;Benzenesulfonamide, 4-methoxy-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-
CBNumber: CB42667261
Molecular Formula: C20H18N2O4S
Formula Weight: 382.43
MOL File: 173529-10-7.mol

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HMN 176 Property

Boiling point:: 632.9±65.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : ≥ 30 mg/mL (78.45 mM)
pka: 8.07±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Ambeed

Product number: A186241
Product name: HMN-176
Purity: 98+%
Packaging: 2mg
Price: $44
Updated: 2021/12/16

CSNpharm

Product number: CSN19103
Product name: HMN-176
Packaging: 1mg
Price: $47
Updated: 2021/12/16

Arctom

Product number: AS031160
Product name: HMN-176
Purity: ≥98%
Packaging: 5mg
Price: $89
Updated: 2021/12/16

Ambeed

Product number: A186241
Product name: HMN-176
Purity: 98+%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

Ambeed

Product number: A186241
Product name: HMN-176
Purity: 98+%
Packaging: 10mg
Price: $117
Updated: 2021/12/16

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HMN 176 Chemical Properties,Usage,Production

Uses

HMN-176?is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization.?

in vivo

After p.o. of HMN-214 to male rats, the prodrug is not detected in the plasma, while plasma levels of HMN-176 peaks at 2 h and gradually decreases thereafter^[3].

References

[1] DiMaio MA, et al. The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by inhibiting centrosome-dependent microtubule nucleation. Mol Cancer Ther. 2009 Mar;8(3):592-601. DOI:10.1158/1535-7163.MCT-08-0876
[2] Medina-Gundrum L, et al. Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression. Invest New Drugs. 2005 Jan;23(1):3-9. DOI:10.1023/B:DRUG.0000047100.64540.f6
[3] Takagi M, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs. 2003 Nov;21(4):387-99. DOI:10.1023/a:1026282716250
[4] Tanaka H, et al. HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res. 2003 Oct 15;63(20):6942-7. PMID:14583495
[5] Garland LL, et al. A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. Clin Cancer Res. 2006 Sep 1;12(17):5182-9. DOI:10.1158/1078-0432.CCR-06-0214

HMN 176 Preparation Products And Raw materials

Raw materials

Preparation Products

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HMN 176 Suppliers

China 57 India 1 United States 8 Global 66

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10410
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

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View Lastest Price from HMN 176 manufacturers

Career Henan Chemical Co

Product: HMN 176 173529-10-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

173529-10-7, HMN 176Related Search:

HMN 176

HMN-176

(NE)-N-[(6E)-6-[2-(1-hydroxypyridin-4-ylidene)ethylidene]cyclohexa-2,4-dien-1-ylidene]-4-methoxybenzenesulfonamide

CS-2239

HMN 176; HMN176

Benzenesulfonamide, 4-methoxy-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-

Polo-like Kinase (PLK),HMN-176,HMN176,HMN 176,Inhibitor,inhibit

(E)-4-(2-((4-Methoxyphenyl)sulfonamido)styryl)pyridine 1-oxide

4-methoxy-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-benzenesulfonamide

HMN-176, 10 mM in DMSO

HMN-176 ，S5807

173529-10-7

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