RP-64477
- Product Name
- RP-64477
- CAS No.
- 135239-65-5
- Chemical Name
- RP-64477
- Synonyms
- RP-64477;RP-64477, 10 mM in DMSO;Benzamide, N-butyl-3-[[4-(decyloxy)benzoyl]amino]-4-(methylthio)-;RP-64477,Diglyceride acyltransferase,RP 64477,inhibit,mono- acylglycerol acyltransferase,Acyltransferase,Inhibitor,acyl-CoA:cholesterol acyltransferase,Diacylglycerol acyltransferase
- CBNumber
- CB42667296
- Molecular Formula
- C29H42N2O3S
- Formula Weight
- 498.72
- MOL File
- 135239-65-5.mol
RP-64477 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 8.33 mg/mL (16.70 mM)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0006335
- Product name
- RP-64477
- Purity
- 99.68%
- Packaging
- 1mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- CS-0006335
- Product name
- RP-64477
- Purity
- 99.68%
- Packaging
- 5mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- CS-0006335
- Product name
- RP-64477
- Purity
- 99.68%
- Packaging
- 10mg
- Price
- $1600
- Updated
- 2021/12/16
- Product number
- 020437
- Product name
- RP-64477
- Packaging
- 001
- Price
- $600
- Updated
- 2021/12/16
- Product number
- CSN22500
- Product name
- RP-64477
- Packaging
- 5mg
- Price
- $720
- Updated
- 2021/12/16
RP-64477 Chemical Properties,Usage,Production
Uses
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).
in vivo
Administration of RP-64477 (0.01% and 0.03% w/w by diet) reduces significantly plasma cholesterol levels in cholesterol/cholic acid-fed rats by 29% and 61%, respectively. Food consumption is not affected by dietary incorporation of RP-64477. Animals receiving RP-64477 (10 and 30 mg/kg b.i.d.) over this period exhibit significantly lower plasma cholesterol levels on both days 4 and 7 when compare to values recorded from vehicle treated animals fed the cholesterol-containing diet. Compare to cholesterol-fed controls, after 7 days of dosing, plasma cholesterol levels are 35% and 53% lower in animals receiving 10 and 30 mg/kg b.i.d. doses of RP-64477, respectively[1].
References
[1] Bello AA, et al. RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol. 1996 Feb 23;51(4):413-21. DOI:10.1016/0006-2952(95)02186-8
RP-64477 Preparation Products And Raw materials
Raw materials
Preparation Products
RP-64477 Suppliers
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