ChemicalBook > CAS DataBase List > RK-20449 trihydrochloride

RK-20449 trihydrochloride

Product Name: RK-20449 trihydrochloride
CAS No.: 1435934-25-0
Chemical Name: RK-20449 trihydrochloride
Synonyms: A 419259 3HCl;A-419259 (hydrochloride);RK20449 trihydrochloride;RK-20449 trihydrochloride;RK 20449 trihydrochloride;A419259; A-419259 TRIHYDROCHLORIDE;RK 20449 trihydrochloride,A 419259 trihydrochloride,Src,Inhibitor,inhibit;7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride;7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride (1:3);rel-7-((1r,4r)-4-(4-Methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
CBNumber: CB42667463
Molecular Formula: C29H35ClN6O
Formula Weight: 519.09
MOL File: 1435934-25-0.mol

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RK-20449 trihydrochloride Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18168
Product name: A-419259 (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18168
Product name: A-419259 (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 18168
Product name: A-419259 (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $299
Updated: 2024/03/01

Cayman Chemical

Product number: 18168
Product name: A-419259 (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $692
Updated: 2024/03/01

TRC

Product number: A101040
Product name: A-419259 trihydrochloride
Packaging: 50mg
Price: $1105
Updated: 2021/12/16

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RK-20449 trihydrochloride Chemical Properties,Usage,Production

Uses

A 419259 Trihydrochloride is the hydrochloride form of A 419259 which is a Src kinase inhibitor and can be used in treatment of chronic myelogenous leukemia, lymphangioleiomyomatosis and tuberous sclerosis.

Biological Activity

a 419259 trihydrochloride is an orally available inhibitor of lck with ic50 value of 15 nm [1].lck is a src family tyrosine kinase. inhibition of this enzyme results in a prevention of t-cell activation and provides an application for treating t-cell dependent processes such as autoimmune and inflammatory diseases. a 419259 trihydrochloride is screened out by its potent inhibitory activity against the recombinant lck (64–509) with ic50 value of 15nm. it is also a selective inhibitor. it shows inactive against a panel of other kinases including cmet, igfr, pkc and pdgfr. besides that, a 419259 trihydrochloride is found to inhibit the production of il-2 with ic50 value of 25nm in jurkat cells. moreover, administration of a 419259 trihydrochloride reduces il-2 production in mice with ed50 value of 2.5 mg/kg. a 419259 trihydrochloride also has efficacy of the antigen specific t-cell immune response. administration of this compound inhibits ifn-γ production during the in vivo priming phase [1].

storage

Desiccate at RT

References

[1] calderwood d j, johnston d n, munschauer r, et al. pyrrolo [2, 3-d] pyrimidines containing diverse n-7 substituents as potent inhibitors of lck. bioorganic & medicinal chemistry letters, 2002, 12(12): 1683-1686.

RK-20449 trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from RK-20449 trihydrochloride manufacturers

Career Henan Chemical Co

Product: RK-20449 trihydrochloride 1435934-25-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-13

1435934-25-0, RK-20449 trihydrochlorideRelated Search:

Piperazine

RK 20449 trihydrochloride

RK20449 trihydrochloride

RK-20449 trihydrochloride

7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride (1:3)

A-419259 (hydrochloride)

A 419259 3HCl

A419259 TRIHYDROCHLORIDE;A-419259 TRIHYDROCHLORIDE;RK 20449 TRIHYDROCHLORIDE;RK20449 TRIHYDROCHLORIDE;RK-20449 TRIHYDROCHLORIDE

A419259; A-419259 TRIHYDROCHLORIDE

7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride

RK 20449 trihydrochloride,A 419259 trihydrochloride,Src,Inhibitor,inhibit

rel-7-((1r,4r)-4-(4-Methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride

1435934-25-0

C29H34N6O3HCl

C29H37Cl3N6O

API