ChemicalBook > CAS DataBase List > RK-20449 trihydrochloride
RK-20449 trihydrochloride
- Product Name
- RK-20449 trihydrochloride
- CAS No.
- 1435934-25-0
- Chemical Name
- RK-20449 trihydrochloride
- Synonyms
- A 419259 3HCl;A-419259 (hydrochloride);RK20449 trihydrochloride;RK-20449 trihydrochloride;RK 20449 trihydrochloride;A419259; A-419259 TRIHYDROCHLORIDE;RK 20449 trihydrochloride,A 419259 trihydrochloride,Src,Inhibitor,inhibit;7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride;7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride (1:3);rel-7-((1r,4r)-4-(4-Methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
- CBNumber
- CB42667463
- Molecular Formula
- C29H35ClN6O
- Formula Weight
- 519.09
- MOL File
- 1435934-25-0.mol
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RK-20449 trihydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- color
- White to yellow
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 18168
- Product name
- A-419259 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18168
- Product name
- A-419259 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18168
- Product name
- A-419259 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $299
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18168
- Product name
- A-419259 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $692
- Updated
- 2024/03/01
TRC
- Product number
- A101040
- Product name
- A-419259 trihydrochloride
- Packaging
- 50mg
- Price
- $1105
- Updated
- 2021/12/16
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RK-20449 trihydrochloride Chemical Properties,Usage,Production
Uses
A 419259 Trihydrochloride is the hydrochloride form of A 419259 which is a Src kinase inhibitor and can be used in treatment of chronic myelogenous leukemia, lymphangioleiomyomatosis and tuberous sclerosis.
Biological Activity
a 419259 trihydrochloride is an orally available inhibitor of lck with ic50 value of 15 nm [1].lck is a src family tyrosine kinase. inhibition of this enzyme results in a prevention of t-cell activation and provides an application for treating t-cell dependent processes such as autoimmune and inflammatory diseases. a 419259 trihydrochloride is screened out by its potent inhibitory activity against the recombinant lck (64–509) with ic50 value of 15nm. it is also a selective inhibitor. it shows inactive against a panel of other kinases including cmet, igfr, pkc and pdgfr. besides that, a 419259 trihydrochloride is found to inhibit the production of il-2 with ic50 value of 25nm in jurkat cells. moreover, administration of a 419259 trihydrochloride reduces il-2 production in mice with ed50 value of 2.5 mg/kg. a 419259 trihydrochloride also has efficacy of the antigen specific t-cell immune response. administration of this compound inhibits ifn-γ production during the in vivo priming phase [1].
storage
Desiccate at RT
References
[1] calderwood d j, johnston d n, munschauer r, et al. pyrrolo [2, 3-d] pyrimidines containing diverse n-7 substituents as potent inhibitors of lck. bioorganic & medicinal chemistry letters, 2002, 12(12): 1683-1686.
RK-20449 trihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from RK-20449 trihydrochloride manufacturers
Career Henan Chemical Co
- Product
- RK-20449 trihydrochloride 1435934-25-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-13