ChemicalBook > CAS DataBase List > HM 30181A

HM 30181A

Product Name: HM 30181A
CAS No.: 849675-66-7
Chemical Name: HM 30181A
Synonyms: HM30181;HM 30181A;HM30181;HM30181A;HM30181(Encequidar);Encequidar (HM-30181;Encequidar, 10 mM in DMSO;N-(2-(2-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide;MDR1,P-gp,Cluster of differentiation 243,inhibit,HM 30181,Encequidar,P-glycoprotein,Multidrug resistance protein 1,Inhibitor,CD243,Pgp,ABCB1,HM-30181;4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-
CBNumber: CB42667519
Molecular Formula: C38H36N6O7
Formula Weight: 688.73
MOL File: 849675-66-7.mol

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HM 30181A Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:30.0(Max Conc. mg/mL);43.56(Max Conc. mM)
form: A crystalline solid
pka: 7.95±0.70(Predicted)
color: Light yellow to yellow
InChIKey: AHJUHHDDCJQACA-UHFFFAOYSA-N
SMILES: C1(C(NC2=CC(OC)=C(OC)C=C2C2=NN(C3=CC=C(CCN4CCC5=C(C4)C=C(OC)C(OC)=C5)C=C3)N=N2)=O)OC2=CC=CC=C2C(=O)C=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6194
Product name: Encequidar
Purity: ≥98.0%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-6194
Product name: Encequidar
Purity: ≥98.0%
Packaging: 50mg
Price: $504
Updated: 2021/12/16

ChemScene

Product number: CS-6194
Product name: Encequidar
Purity: ≥98.0%
Packaging: 100mg
Price: $708
Updated: 2021/12/16

DC Chemicals

Product number: DC10414
Product name: HM30181(Encequidar)
Purity: >98%
Packaging: 250mg
Price: $800
Updated: 2021/12/16

Crysdot

Product number: CD11046631
Product name: HM-30181-A
Purity: 95+%
Packaging: 5mg
Price: $69
Updated: 2021/12/16

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HM 30181A Chemical Properties,Usage,Production

Uses

Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein.

in vivo

PET scans with the Pgp substrate (R)-[¹¹C]NSC 657799 in FVB wild-type mice pretreated i.v. with Encequidar (HM30181) (10 or 21 mg/kg) failes to show significant increases in (R)-[¹¹C]NSC 657799 brain uptake compared with vehicle treated animals^[1]. Encequidar (HM30181) inhibits P-gp mainly in the intestinal endothelium, which can be beneficial because pan-inhibition of P-gp, particularly in the brain, could lead to detrimental adverse events. Encequidar (HM30181) increases the oral bioavailability of co-administered NSC 125973 by more than 12 times in rats^[2].

References

[1] Bauer F, et al. Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography. Eur J Pharmacol. 2012 Dec 5;696(1-3):18-27. DOI:10.1016/j.ejphar.2012.09.013
[2] Kim TE, et al. Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. Br J Clin Pharmacol. 2014 Sep;78(3):556-64. DOI:10.1111/bcp.12368

HM 30181A Preparation Products And Raw materials

Raw materials

Preparation Products

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849675-66-7, HM 30181ARelated Search:

HM 30181A

HM30181

HM30181;HM30181A

4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-

HM30181(Encequidar)

Encequidar (HM-30181

MDR1,P-gp,Cluster of differentiation 243,inhibit,HM 30181,Encequidar,P-glycoprotein,Multidrug resistance protein 1,Inhibitor,CD243,Pgp,ABCB1,HM-30181

Encequidar, 10 mM in DMSO

N-(2-(2-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide

849675-66-7

C38H36N6O7