ChemicalBook > CAS DataBase List > CTEP Derivative
CTEP Derivative
- Product Name
- CTEP Derivative
- CAS No.
- 802906-73-6
- Chemical Name
- CTEP Derivative
- Synonyms
- RG7090;RG-7090;RG 7090;Ro 4917523;RO 491752);BasiMglurant;CTEP Derivative;Basimglurant(RG7090;RG7090(Basimglurant);Basimglurant, 10 mM in DMSO
- CBNumber
- CB42667665
- Molecular Formula
- C18H13ClFN3
- Formula Weight
- 325.77
- MOL File
- 802906-73-6.mol
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CTEP Derivative Property
- Melting point:
- 132 - 135°C
- Boiling point:
- 526.6±60.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 5.27±0.70(Predicted)
- form
- Solid
- color
- Pale Brown to Light Brown
- Stability:
- Hygroscopic, Moisture Sensitive
- InChI
- InChI=1S/C18H13ClFN3/c1-12-17(8-3-14-9-10-21-18(19)11-14)22-13(2)23(12)16-6-4-15(20)5-7-16/h4-7,9-11H,1-2H3
- InChIKey
- UPZWINBEAHDTLA-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(C#CC2=C(C)N(C3=CC=C(F)C=C3)C(C)=N2)=C1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-3388
- Product name
- Basimglurant
- Purity
- 99.56%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB103175
- Product name
- Basimglurant
- Packaging
- 25mg
- Price
- $450
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3388
- Product name
- Basimglurant
- Purity
- 99.56%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB103175
- Product name
- Basimglurant
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B4808
- Product name
- RG7090
- Packaging
- 10mg
- Price
- $788
- Updated
- 2021/12/16
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CTEP Derivative Chemical Properties,Usage,Production
Uses
Basimglurant is a potent, selective and orally available mGlu5 negative allosteric modulator for the treatment of mood disorders.
in vivo
Basimglurant (RG7090) is a potent, selective, and safe mGlu5 inhibitor with good oral bioavailability and long half-life supportive of once-daily administration, good brain penetration, and high in vivo potency. It has antidepressant properties which are corroborated by its functional magnetic imaging (fMRI) profile, as well as anxiolytic-like and antinociceptive features[1]. It is currently in phase II clinical studies for the treatment of depression and fragile X syndrome. In the Vogel conflict drinking test, Basimglurant dose dependently increases the drinking time. The total plasma exposure of efficacious doses of Basimglurant (RG7090) ranges from 5 ng/mL (0.03 mg/kg) to 37 ng/mL (0.3 mg/kg)[2].
IC 50
mGlu5 Receptor: 1.1 nM (Kd)
CTEP Derivative Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CTEP Derivative manufacturers
Career Henan Chemical Co
- Product
- CTEP Derivative 802906-73-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23