PF 4957325
- Product Name
- PF 4957325
- CAS No.
- 1305115-80-3
- Chemical Name
- PF 4957325
- Synonyms
- PF 4957325;PF 04957325;PF-04957325;PF04957325; PF4957325;PF04957325,PF 04957325;PF-04957325, 10 mM in DMSO;3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine;(R)-3-((4-(thiazol-2-ylmethyl)morpholin-2-yl)methyl)-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine;3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine, 3-[[(2R)-4-(2-thiazolylmethyl)-2-morpholinyl]methyl]-5-(trifluoromethyl)-;3-{[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine
- CBNumber
- CB42668374
- Molecular Formula
- C14H15F3N8OS
- Formula Weight
- 400.38
- MOL File
- 1305115-80-3.mol
PF 4957325 Property
- Density
- 1.81±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 9.9 mg/mL (24.73 mM)
- pka
- 4.51±0.10(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- PZ0407
- Product name
- PF-04957325
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $62.28
- Updated
- 2025/07/31
- Product number
- PZ0407
- Product name
- PF-04957325
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $265
- Updated
- 2025/07/31
- Product number
- CS-6185
- Product name
- PF-04957325
- Purity
- 99.94%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-6185
- Product name
- PF-04957325
- Purity
- 99.94%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CS-6185
- Product name
- PF-04957325
- Purity
- 99.94%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
PF 4957325 Chemical Properties,Usage,Production
Uses
PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
References
[1] Vang AG, et al. Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation. Front Pharmacol. 2016 Aug 23;7:259. DOI:10.3389/fphar.2016.00259
[2] Dong H, et al. Inhibition of breast cancer cell migration by activation of cAMP signaling. Breast Cancer Res Treat. 2015 Jul;152(1):17-28. DOI:10.1007/s10549-015-3445-9
[3] Tsai LC, et al. Regulation of adrenal steroidogenesis by the high-affinity phosphodiesterase 8 family. Horm Metab Res. 2012 Sep;44(10):790-4. DOI:10.1055/s-0032-1321861
[4] Shimizu-Albergine M, et al. cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis. Mol Pharmacol. 2012 Apr;81(4):556-66. DOI:10.1124/mol.111.076125
PF 4957325 Preparation Products And Raw materials
Raw materials
Preparation Products
PF 4957325 Suppliers
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