HM30181 (Mesylate)
- Product Name
- HM30181 (Mesylate)
- CAS No.
- 849675-87-2
- Chemical Name
- HM30181 (Mesylate)
- Synonyms
- Encequidar mesylate;HM30181A mesylate;HM30181 (Mesylate);PEKXWELLWNPUOK-UHFFFAOYSA-N;Encequidar mesylate (HM-30181;Encequidar mesylate, 10 mM in DMSO;HM30181 mesylate (Encequidar mesylate);Encequidar mesylate (HM30181 (mesylate));HM30181 mesylate (Synonyms: Encequidar mesylate);N-(2-(2-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate
- CBNumber
- CB42668516
- Molecular Formula
- C39H40N6O10S
- Formula Weight
- 784.84
- MOL File
- 849675-87-2.mol
HM30181 (Mesylate) Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:25.0(Max Conc. mg/mL);31.85(Max Conc. mM)
- form
- Solid
- color
- Light yellow to yellow
- InChIKey
- PEKXWELLWNPUOK-UHFFFAOYSA-N
- SMILES
- S(O)(=O)(=O)C.N(C1C=C(OC)C(OC)=CC=1C1N=NN(C2C=CC(CCN3CCC4=CC(OC)=C(OC)C=C4C3)=CC=2)N=1)C(C1=CC(=O)C2=CC=CC=C2O1)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0007532
- Product name
- Encequidar(mesylate)
- Purity
- 99.84%
- Packaging
- 50mg
- Price
- $504
- Updated
- 2021/12/16
- Product number
- CS-0007532
- Product name
- Encequidar(mesylate)
- Purity
- 99.84%
- Packaging
- 100mg
- Price
- $708
- Updated
- 2021/12/16
- Product number
- orb573200
- Product name
- HM30181 mesylate
- Packaging
- 100mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- CS-0007532
- Product name
- Encequidar(mesylate)
- Purity
- 99.84%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0007532
- Product name
- Encequidar(mesylate)
- Purity
- 99.84%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
HM30181 (Mesylate) Chemical Properties,Usage,Production
Uses
Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor.
in vivo
The plasma concentrations of Encequidar (HM30181) are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar (HM30181) in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction[1].
References
[1] Kim JC, et al. Effect of HM30181 mesylate salt-loaded microcapsules on the oral absorption of NSC 125973 as a novel P-glycoprotein inhibitor. Int J Pharm. 2016 Jun 15;506(1-2):93-101. DOI:10.1016/j.ijpharm.2016.04.034
[2] Joo KM, et al. Response of brain specific microenvironment to P-glycoprotein inhibitor: an important factor determining therapeutic effect of P-glycoprotein inhibitor on brain metastatic tumors. Int J Oncol. 2008 Oct;33(4):705-12. PMID:18813783
HM30181 (Mesylate) Preparation Products And Raw materials
Raw materials
Preparation Products
HM30181 (Mesylate) Suppliers
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View Lastest Price from HM30181 (Mesylate) manufacturers
- Product
- HM30181 (Mesylate) 849675-87-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26