ChemicalBook > CAS DataBase List > 3,6-difluoropyridin-2-aMine
3,6-difluoropyridin-2-aMine
- Product Name
- 3,6-difluoropyridin-2-aMine
- CAS No.
- 944799-22-8
- Chemical Name
- 3,6-difluoropyridin-2-aMine
- Synonyms
- 3,6-difluoropyridin-2-aMine;3,6-difluoro-2-pyridinamine;2-Pyridinamine, 3,6-difluoro-
- CBNumber
- CB42669593
- Molecular Formula
- C5H4F2N2
- Formula Weight
- 130.1
- MOL File
- 944799-22-8.mol
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3,6-difluoropyridin-2-aMine Property
- Boiling point:
- 190.0±35.0 °C(Predicted)
- Density
- 1.393±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 0.57±0.10(Predicted)
- Appearance
- Off-white to gray Solid
- InChI
- InChI=1S/C5H4F2N2/c6-3-1-2-4(7)9-5(3)8/h1-2H,(H2,8,9)
- InChIKey
- HMRIDZSIODFQSH-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(F)=CC=C1F
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- D455995
- Product name
- 3,6-difluoropyridin-2-amine
- Packaging
- 25mg
- Price
- $350
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC201381
- Product name
- 3,6-Difluoropyridin-2-amine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $383
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC201381
- Product name
- 3,6-Difluoropyridin-2-amine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $97
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC201381
- Product name
- 3,6-Difluoropyridin-2-amine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $153
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H30-3-6M
- Product name
- 3,6-Difluoropyridin-2-amine
- Purity
- 95.0%
- Packaging
- 100mg
- Price
- $156
- Updated
- 2021/12/16
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3,6-difluoropyridin-2-aMine Chemical Properties,Usage,Production
Synthesis
3512-18-3
944799-22-8
Under argon protection, 2,3,6-trifluoropyridine (5 g, 37.59 mmol) was dissolved in 1,4-dioxane (20 mL) and stirred until completely dissolved. Subsequently, ammonia (20 mL) was slowly added to the solution. The reaction mixture was stirred continuously at 100 °C for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of 2,3,6-trifluoropyridine, the reaction was quenched with cold water (500 mL). The reaction mixture was extracted with dichloromethane (2 x 500 mL) and the organic phases were combined. The organic phase was dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 3,6-difluoropyridin-2-amine (3 g, 62% yield) as an off-white solid, which could be used for subsequent reactions without further purification.TLC conditions: 10% ethyl acetate/hexane (Rf: 0.5).
References
[1] Patent: WO2007/87549, 2007, A2. Location in patent: Page/Page column 117
[2] Patent: WO2015/109109, 2015, A1. Location in patent: Paragraph 0742
[3] Patent: US2017/44182, 2017, A1. Location in patent: Paragraph 1026
3,6-difluoropyridin-2-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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