(3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

Product Name: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
CAS No.: 1005036-73-6
Chemical Name: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Synonyms: GCA;(Rac)-GCA;CID 25113626;rac-Golgicide A;Recombinant Human Grancalcin/GCA Protein, Gst Tag;3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-;(3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
CBNumber: CB42676070
Molecular Formula: C17H14F2N2
Formula Weight: 284.3032664
MOL File: 1005036-73-6.mol

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(3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline Property

Boiling point:: 383.0±42.0 °C(Predicted)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: >10mg/mL
form: solid
pka: 4.84±0.12(Predicted)
InChI: 1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16/m0/s1
InChIKey: NJZHEQOUHLZCOX-FTLRAWMYSA-N
SMILES: Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4

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Safety

WGK Germany: 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G0923
Product name: Golgicide A
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $205
Updated: 2026/03/19

Sigma-Aldrich

Product number: G0923
Product name: Golgicide A
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $749
Updated: 2026/03/19

Cayman Chemical

Product number: 18430
Product name: Golgicide A
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 18430
Product name: Golgicide A
Purity: ≥98%
Packaging: 10mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 18430
Product name: Golgicide A
Purity: ≥98%
Packaging: 25mg
Price: $278
Updated: 2024/03/01

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(3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline Chemical Properties,Usage,Production

Uses

Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells.

Definition

ChEBI: 6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is an organic heterotricyclic compound that is 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline which is substituted by a pyridin-3-yl at position 4 and by fluorines at positions 6 and 8. It is an organic heterotricyclic compound, a member of pyridines, an organofluorine compound and a secondary amino compound.

Biochem/physiol Actions

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.

(3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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(3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline Suppliers

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1005036-73-6, (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolineRelated Search:

(3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

CID 25113626

GCA

rac-Golgicide A

Recombinant Human Grancalcin/GCA Protein, Gst Tag

(Rac)-GCA

3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-

1005036-73-6