Btk inhibitor 1

Product Name: Btk inhibitor 1
CAS No.: 1412418-47-3
Chemical Name: Btk inhibitor 1
Synonyms: (Rac)-IBT6A;Btk inhibitor 1;(Rac)-IBT6A, 10 mM in DMSO;Phenylpyruvic Acid Impurity 5;BTK INHIBITOR 1 (IBRUTINIB ANALOG RACEMATE);3-(4-phenoxyphenyl)-1-piperidin-3-ylpyrazolo[3,4-d]pyrimidin-4-amine;3-(4-Phenoxyphenyl)-1-(3-piperidyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(3-piperidinyl)-;3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine;Bruton tyrosine kinase,Inhibitor,(Rac)-IBT6A,inhibit,(Rac)IBT6A,Btk,(Rac) IBT6A,(Rac)-IBT-6A
CBNumber: CB42677057
Molecular Formula: C22H22N6O
Formula Weight: 386.45
MOL File: 1412418-47-3.mol

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Btk inhibitor 1 Property

Boiling point:: 626.3±55.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (129.38 mM; Need ultrasonic)
form: Powder
pka: 9.00±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1800
Product name: (Rac)-IBT6A
Purity: 97.61%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-1800
Product name: (Rac)-IBT6A
Purity: 97.61%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573382
Product name: BTK inhibitor 1
Purity: >98%
Packaging: 100mg
Price: $912.9
Updated: 2021/12/16

ChemScene

Product number: CS-1800
Product name: (Rac)-IBT6A
Purity: 97.61%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573382
Product name: BTK inhibitor 1
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

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Btk inhibitor 1 Chemical Properties,Usage,Production

Uses

(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].

References

[1] Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.
[2] Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80. DOI:10.1073/pnas.1004594107
[3] Liu N, et al. Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study. Org Biomol Chem. 2015 May 14;13(18):5147-57. DOI:10.1039/c5ob00474h

Btk inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Btk inhibitor 1 Suppliers

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1412418-47-3