QL47

Product Name: QL47
CAS No.: 1469988-75-7
Chemical Name: QL47
Synonyms: QL47;QL47,QL-47;BTK Inhibitor;BMX/BTK Inhibitor II, QL47;Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[2,3-dihydro-1-(1-oxo-2-propen-1-yl)-1H-indol-6-yl]-9-(1-methyl-1H-pyrazol-4-yl)-
CBNumber: CB42682020
Molecular Formula: C27H21N5O2
Formula Weight: 447.49
MOL File: 1469988-75-7.mol

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QL47 Property

Boiling point:: 706.2±60.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : < 1 mg/mL (insoluble or slightly soluble)
form: Powder
pka: 4?+-.0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.30758
Product name: BMX/BTK Inhibitor II, QL47 - CAS 1469988-75-7 - Calbiochem
Purity: A cell-permeable, highly potent, selective, irreversible inhibitor of BTK (IC?? = 6.6 nM).
Packaging: 5MG
Price: $161
Updated: 2025/07/31

ChemScene

Product number: CS-2151
Product name: QL47
Purity: 98.63%
Packaging: 5mg
Price: $168
Updated: 2021/12/16

ChemScene

Product number: CS-2151
Product name: QL47
Purity: 98.63%
Packaging: 10mg
Price: $264
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611738
Product name: QL-47
Packaging: 10mg
Price: $368.9
Updated: 2021/12/16

ChemScene

Product number: CS-2151
Product name: QL47
Purity: 98.63%
Packaging: 50mg
Price: $1056
Updated: 2021/12/16

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QL47 Chemical Properties,Usage,Production

Uses

QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM[1][2][3].

Definition

ChEBI: 9-(1-methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone is a naphthyridine derivative.

Biological Activity

Cell permeable: yes', 'Primary Target
BMX & BTK', 'Reversible: no

References

[1] Liang Y, et al. Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent. ACS Med Chem Lett. 2017;8(3):344-349. Published 2017 Feb 3. DOI:10.1021/acsmedchemlett.7b00008
[2] de Wispelaere M, et al. A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. J Biol Chem. 2020;295(6):1694-1703. DOI:10.1074/jbc.RA119.011132
[3] Wu H, et al. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol. 2014;9(5):1086-1091. DOI:10.1021/cb4008524

QL47 Preparation Products And Raw materials

Raw materials

Preparation Products

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QL47 Suppliers

CHINA 35 United States 4 Global 39

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

1469988-75-7, QL47Related Search:

QL47

BTK Inhibitor

Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[2,3-dihydro-1-(1-oxo-2-propen-1-yl)-1H-indol-6-yl]-9-(1-methyl-1H-pyrazol-4-yl)-

QL47,QL-47

BMX/BTK Inhibitor II, QL47

1469988-75-7