(R)-Methyl 2,3-dihydroxypropanoate

Product Name: (R)-Methyl 2,3-dihydroxypropanoate
CAS No.: 18289-89-9
Chemical Name: (R)-Methyl 2,3-dihydroxypropanoate
Synonyms: Methyl D-(-)-glycerate;methyl (R)-2,3-dihydroxypropanoate;(R) Methyl-2,3-dihydroxypropionate;Methyl (R)-2,3-Dihydroxypropionate;(R)-Methyl 2,3-dihydroxypropanoate;methyl (2R)-2,3-dihydroxypropanoate;Propanoic acid, 2,3-dihydroxy-, methyl ester, (2R)-
CBNumber: CB42685319
Molecular Formula: C4H8O4
Formula Weight: 120.1
MOL File: 18289-89-9.mol

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(R)-Methyl 2,3-dihydroxypropanoate Property

Boiling point:: 140 °C(Press: 15 Torr)
Density: 1.2795 g/cm3
storage temp.: 2-8°C
pka: 12.26±0.20(Predicted)
Appearance: Light yellow to yellow Liquid
optical activity: 12.5°(C=0.01g/ml CHCL3)
InChI: InChI=1S/C4H8O4/c1-8-4(7)3(6)2-5/h3,5-6H,2H2,1H3/t3-/m1/s1
InChIKey: COFCNNXZXGCREM-GSVOUGTGSA-N
SMILES: C(OC)(=O)[C@H](O)CO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M507550
Product name: (R)-Methyl2,3-dihydroxypropanoate
Packaging: 50mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 9042AH
Product name: (R)-Methyl2,3-dihydroxypropanoate
Packaging: 1g
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: 9042AH
Product name: (R)-Methyl2,3-dihydroxypropanoate
Packaging: 25g
Price: $1141
Updated: 2021/12/16

J&W Pharmlab

Product number: 05R0668
Product name: (R)-2,3-DIHYDROXY-PROPIONICACIDMETHYLESTER
Purity: 96%
Packaging: 5g
Price: $1500
Updated: 2021/12/16

Ambeed

Product number: A227282
Product name: (R)-Methyl2,3-dihydroxypropanoate
Purity: 97%
Packaging: 250mg
Price: $34
Updated: 2021/12/16

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(R)-Methyl 2,3-dihydroxypropanoate Chemical Properties,Usage,Production

Synthesis

52373-72-5

18289-89-9

General procedure for the synthesis of methyl (R)-2,3-dihydroxypropionate from methyl (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate: 1. dissolve methyl (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (1 g, 6.24 mmol) in a mixed solvent of acetic acid (14 ml) and water (6 ml). 2. The reaction mixture was stirred at room temperature for 18 hours. 3. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. 4. The resulting residue was distilled three times azeotropically with toluene to completely remove water and residual acetic acid. 5. Methyl (R)-2,3-dihydroxypropionate (610.6 mg, 81% yield) was finally obtained. Product characterization data: 1H NMR (CDCl3, 400MHz) δ 4.29 (dd, 1H, J = 3.8, 3.3Hz), 3.91 (dd, 1H, J = 11.7, 3.3Hz), 3.85 (dd, 1H, J = 11.7, 3.8Hz), 3.84 (s, 3H).

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 17, p. 3223 - 3230
[2] Acta Chemica Scandinavica, 1998, vol. 52, # 6, p. 819 - 823
[3] Patent: US2006/270634, 2006, A1. Location in patent: Page/Page column 2; sheet 4
[4] Angewandte Chemie - International Edition, 2015, vol. 54, # 34, p. 9898 - 9902
[5] Angew. Chem., 2015, vol. 127, # 34, p. 10036 - 10040,5

(R)-Methyl 2,3-dihydroxypropanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-Methyl 2,3-dihydroxypropanoate Suppliers

China 40 India 1 United States 3 Global 44

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18289-89-9, (R)-Methyl 2,3-dihydroxypropanoateRelated Search:

Protocatechualdehyde

methyl (2R)-2,3-dihydroxypropanoate

Propanoic acid, 2,3-dihydroxy-, methyl ester, (2R)-

(R)-Methyl 2,3-dihydroxypropanoate

Methyl D-(-)-glycerate

Methyl (R)-2,3-Dihydroxypropionate

(R) Methyl-2,3-dihydroxypropionate

methyl (R)-2,3-dihydroxypropanoate

18289-89-9