PTP Inhibitor V, PHPS1
- Product Name
- PTP Inhibitor V, PHPS1
- CAS No.
- 314291-83-3
- Chemical Name
- PTP Inhibitor V, PHPS1
- Synonyms
- PHPS1;PHPS1 sodium salt;PTP Inhibitor V, PHPS1;PHPS1 sodium salt hydrate;PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem;4-(2-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid;Benzenesulfonic acid, 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-;atherosclerosis,kidney,Erk1/2,inhibit,PTP1B,prostate,Shp1,PHPS1,colon,Phosphatase,lung,Shp2,carcinoma,cancer,Inhibitor;4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate
- CBNumber
- CB42685465
- Molecular Formula
- C21H15N5O6S
- Formula Weight
- 465.44
- MOL File
- 314291-83-3.mol
PTP Inhibitor V, PHPS1 Property
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear (warmed)
- pka
- -2.90±0.40(Predicted)
- form
- solid
- color
- red
- InChI
- InChI=1S/C21H15N5O6S/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16/h1-13,22H,(H,30,31,32)
- InChIKey
- VIQSBJOMLQLAKC-UHFFFAOYSA-N
- SMILES
- C1(S(O)(=O)=O)=CC=C(NN=C2C(=O)N(C3=CC=CC=C3)N=C2C2=CC=C([N+]([O-])=O)C=C2)C=C1
Safety
- WGK Germany
- 2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P0039
- Product name
- PHPS1 sodium salt hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $211
- Updated
- 2024/03/01
- Product number
- 540213
- Product name
- PTP Inhibitor V, PHPS1
- Packaging
- 10mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 18856
- Product name
- PHPS1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 18856
- Product name
- PHPS1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- P0039
- Product name
- PHPS1 sodium salt hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $735
- Updated
- 2022/05/15
PTP Inhibitor V, PHPS1 Chemical Properties,Usage,Production
Description
PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of SH-PTP2 (Shp-2) (IC50 and Ki = 2.1 and 0.73μM, respectively). PHPS1 inhibits PCPTP1 (ECPTP), PTP1B, SH-PTP1 (Shp1), mycobacterium MptpA only at higher concentrations (IC50 ;= 5.4, 19, 30, and 39 μM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 μM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation
Uses
Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) sodium salt hydrate has been used as a protein-tyrosine phosphatase (shp2) inhibitor to study its effects on bisphenol A (BPA) and nonyl phenol (NP)-induced cell proliferation of MCF7 cell. It has also been used as a shp2 inhibitor to study its pro-atherosclerotic or atheroprotective effect in vivo and in vitro.
Biochem/physiol Actions
Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) represses E2-induced gene transcription and rapid DNA synthesis. It also blocks mitogen-activated protein kinase (ERK1/2) activation and reduces the cigarette smoke induced-inflammatory response in mouse lungs.
PTP Inhibitor V, PHPS1 Preparation Products And Raw materials
Raw materials
Preparation Products
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