ChemicalBook > CAS DataBase List > AHAS inhibitor
AHAS inhibitor
- Product Name
- AHAS inhibitor
- CAS No.
- 219793-45-0
- Chemical Name
- AHAS inhibitor
- Synonyms
- CS-1880;BTB06584;AHAS inhibitor;BTB06584 >=98% (HPLC);AHAS inhibitor BTB06584;BTB06584, 10 mM in DMSO;AHAS inhibitor USP/EP/BP;BTB 06584;BTB-06584;BTB06584;AHAS inhibitor LM-3254 03-11 cq;-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester
- CBNumber
- CB42685915
- Molecular Formula
- C19H12ClNO6S
- Formula Weight
- 417.82
- MOL File
- 219793-45-0.mol
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AHAS inhibitor Property
- Boiling point:
- 664.8±55.0 °C(Predicted)
- Density
- 1.466±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- solubility
- <2.47 mg/mL in EtOH insoluble in; ≥17.05 mg/mL in DMSO; insoluble in H2O
- form
- solid
- color
- White to off-white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1122
- Product name
- BTB06584
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $153
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B6584
- Product name
- BTB 06584
- Packaging
- 10MG
- Price
- $150
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 21032
- Product name
- BTB06584
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21032
- Product name
- BTB06584
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $356
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21032
- Product name
- BTB06584
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2021/12/16
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AHAS inhibitor Chemical Properties,Usage,Production
Uses
BTB06584 is F1 Fo-ATPase inhibitor. It can be used in biological study of novel acetohydroxyacid synthase inhibitors as active agents against Mycobacterium tuberculosis.
Biological Activity
ischaemia compromises mitochondrial respiration. consequently, the mitochondrial 1fo-atp synthase reverses and plays as a proton-pumping atpase, so maintaining the mitochondrial membrane potential (δψm), while accelerating atp depletion and cell death. btb06584 is an if1-dependent selective inhibitor of the mitochondrial f1fo-atpase.
in vitro
btb inhibited f1fo-atpase activity with no effect on the mitochondrial membrane potential (δψm) or o2 consumption. atp consumption decreased via inhibition of respiration, and ischaemic cell death was reduced. btb efficiency increased by if1 overexpression and reduced by silencing this protein. in addition, btb rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the atpif1a gene is lost [1].
in vivo
the btb-mediated protection was further tested in neurons. primary cultured cortical neurons of mice were exposed to ogd, treated or not with btb, followed by rx. the resulting cell death was significantly reduced by btb, as scored by pi staining, compared with cells left untreated during ogd [1].
References
[1] ivanes f, faccenda d, gatliff j, ahmed aa, cocco s, cheng ch, allan e, russell c, duchen mr, campanella m. the compound btb06584 is an if1-dependent selective inhibitor of the mitochondrial f1 fo-atpase. br j pharmacol. 2014;171(18):4193-206.
AHAS inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
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