ChemicalBook > CAS DataBase List > AP-III-a4

AP-III-a4

Product Name
AP-III-a4
CAS No.
1177827-73-4
Chemical Name
AP-III-a4
Synonyms
CS-1077;ENOBLOCK;AP-III-a4;ENOblock (AP-III-a4);ENOBLOCK HYDROCHLORIDE;AP-III-a4(ENOblock), >98%;Inhibitor,AP-III-a-4,Phosphopyruvate hydratase,Apoptosis,inhibit,antidiabetic,anticancer,HCT116,Enolase,Huh7,zebrafish,APIIIa4,HEK,AP III a4;N-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]benzeneacetamide;Benzeneacetamide, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-;AP-III-A4 Benzeneacetamide, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-
CBNumber
CB42685920
Molecular Formula
C31H43FN8O3
Formula Weight
594.72
MOL File
1177827-73-4.mol
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AP-III-a4 Property

Density 
1.250±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in DMSO
form 
Powder
pka
15.25±0.46(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19933
Product name
AP-III-a4
Purity
≥95%
Packaging
1mg
Price
$71
Updated
2024/03/01
Cayman Chemical
Product number
19933
Product name
AP-III-a4
Purity
≥95%
Packaging
5mg
Price
$313
Updated
2024/03/01
Cayman Chemical
Product number
19933
Product name
AP-III-a4
Purity
≥95%
Packaging
10mg
Price
$590
Updated
2024/03/01
Cayman Chemical
Product number
19933
Product name
AP-III-a4
Purity
≥95%
Packaging
25mg
Price
$855
Updated
2021/12/16
ApexBio Technology
Product number
B3588
Product name
AP-III-a4
Packaging
5mg
Price
$344
Updated
2021/12/16
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AP-III-a4 Chemical Properties,Usage,Production

Uses

AP-III-a4 (ENOblock) is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 can be used for the research of cancer and diabetic[1].

in vivo

AP-III-a4 (ENOblock) (10 μM; 96 h) inhibits cancer cell metastasis and suppresses the gluconeogenesis regulator PEPCK in zebrafish[1].

Animal Model:The zebrafish cancer cell HCT116 xenograft model[1]
Dosage:10 μM
Administration:96 h
Result:Reduced cancer cell dissemination. Inhibited PEPCK expression and induced glucose uptake. Inhibited adipogenesis and foam cell formation.

References

[1] Da-Woon Jung, et al. A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes.ACS Chem. Biol., 2013, 8 (6), pp 1271–1282 DOI:10.1021/cb300687k

AP-III-a4 Preparation Products And Raw materials

Raw materials

Preparation Products

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AP-III-a4 Suppliers

China 68 India 1 United States 13 Global 82
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from AP-III-a4 manufacturers

Career Henan Chemical Co
Product
AP-III-a4 1177827-73-4
Price
US $5.50/g
Min. Order
1g
Purity
98%min
Supply Ability
10g,100g,1kg
Release date
2020-01-09

1177827-73-4, AP-III-a4Related Search:


  • AP-III-a4
  • ENOblock (AP-III-a4)
  • AP-III-A4 Benzeneacetamide, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-
  • N-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]benzeneacetamide
  • AP-III-a4(ENOblock), >98%
  • ENOBLOCK
  • CS-1077
  • ENOBLOCK HYDROCHLORIDE
  • Benzeneacetamide, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-
  • Inhibitor,AP-III-a-4,Phosphopyruvate hydratase,Apoptosis,inhibit,antidiabetic,anticancer,HCT116,Enolase,Huh7,zebrafish,APIIIa4,HEK,AP III a4
  • 1177827-73-4
  • C31H43FN8O3