ChemicalBook > CAS DataBase List > 4-Bromo-2-(difluoromethyl)pyridine

4-Bromo-2-(difluoromethyl)pyridine

Product Name
4-Bromo-2-(difluoromethyl)pyridine
CAS No.
1211580-54-9
Chemical Name
4-Bromo-2-(difluoromethyl)pyridine
Synonyms
4-Bromo-2-(difL;4-Bromo-2-(difluoromethyl)pyridine;Pyridine, 4-bromo-2-(difluoromethyl)-;4-Bromo-2-(difluoromethyl)pyridine 97%;4-Bromo-alpha,alpha-difluoro-2-picoline
CBNumber
CB42688471
Molecular Formula
C6H4BrF2N
Formula Weight
208
MOL File
1211580-54-9.mol
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4-Bromo-2-(difluoromethyl)pyridine Property

Boiling point:
210.3±35.0 °C(Predicted)
Density 
1.640±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.27±0.10(Predicted)
form 
liquid
color 
Colourless to light yellow
InChI
InChI=1S/C6H4BrF2N/c7-4-1-2-10-5(3-4)6(8)9/h1-3,6H
InChIKey
MNMLGZMORMDPJI-UHFFFAOYSA-N
SMILES
C1(C(F)F)=NC=CC(Br)=C1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B997813
Product name
4-Bromo-2-(difluoromethyl)pyridine
Packaging
50mg
Price
$130
Updated
2021/12/16
Apolloscientific
Product number
PC51201
Product name
4-Bromo-2-(difluoromethyl)pyridine
Purity
97%
Packaging
500mg
Price
$143
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-9-D7
Product name
4-Bromo-2-(difluoromethyl)pyridine
Packaging
500mg
Price
$157
Updated
2021/12/16
Apolloscientific
Product number
PC51201
Product name
4-Bromo-2-(difluoromethyl)pyridine
Purity
97%
Packaging
100mg
Price
$66
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-9-D7
Product name
4-Bromo-2-(difluoromethyl)pyridine
Packaging
100mg
Price
$72
Updated
2021/12/16
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4-Bromo-2-(difluoromethyl)pyridine Chemical Properties,Usage,Production

Synthesis

131747-63-2

1211580-54-9

Step 1: Synthesis of 4-bromo-2-(difluoromethyl)pyridine: To 4-bromopyridine-2-carbaldehyde (5.0 g, 26.88 mmol) was added diethylamino sulfur trifluoride (7.03 mL, 53.7 mmol) at room temperature and the reaction mixture was stirred for 16 hours. Upon completion of the reaction, the reaction was quenched with aqueous sodium bicarbonate (50 mL) and subsequently extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, washed with brine (2 x 50 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Purification by silica gel column chromatography (100-200 mesh) using a hexane solution of 5% ethyl acetate as eluent afforded 4-bromo-2-(difluoromethyl)pyridine (3.0 g, 14.492 mmol, 54% yield).1H NMR (400 MHz, CDCl3) δ= 8.48 (d, J = 4.9 Hz, 1H), 7.82 (d, J = 1.5 Hz, 1H), 7.66-7.50 (m, 1H), 6.60 (t, 1H).LCMS: 207.9 [M + H]+.

References

[1] Patent: WO2016/161160, 2016, A1. Location in patent: Paragraph 0207
[2] Patent: US2015/152108, 2015, A1. Location in patent: Paragraph 0480; 0481
[3] Patent: WO2016/79709, 2016, A1. Location in patent: Page/Page column 179
[4] Patent: US2010/125082, 2010, A1. Location in patent: Page/Page column 24; 25
[5] Patent: WO2015/180612, 2015, A1. Location in patent: Page/Page column 78

4-Bromo-2-(difluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromo-2-(difluoromethyl)pyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Bromo-2-(difluoromethyl)pyridine 1211580-54-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-07-07
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-bromo-2-(difluoromethyl)pyridine 1211580-54-9
Price
US $3.00-9.00/KG
Min. Order
0.01KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-21

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