4-((Trimethylsilyl)ethynyl)phenol

Product Name: 4-((Trimethylsilyl)ethynyl)phenol
CAS No.: 88075-18-7
Chemical Name: 4-((Trimethylsilyl)ethynyl)phenol
Synonyms: 185664;4-((Trimethylsilyl)ethynyl)phenol;4-[2-(TriMethylsilyl)ethynyl]-phenol;Phenol, 4-[2-(trimethylsilyl)ethynyl]-;4-((Trimethylsilyl)ethynyl)phenol - [T54814]
CBNumber: CB42693217
Molecular Formula: C11H14OSi
Formula Weight: 190.31
MOL File: 88075-18-7.mol

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4-((Trimethylsilyl)ethynyl)phenol Property

Melting point:: 68 °C
Boiling point:: 251.7±32.0 °C(Predicted)
Density: 1.01±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 9.26±0.26(Predicted)
color: White to light yellow

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Synthonix

Product number: T54814
Product name: 4-((Trimethylsilyl)ethynyl)phenol
Purity: 95+%
Packaging: 250mg
Price: $80
Updated: 2021/12/16

Activate Scientific

Product number: AS45830
Product name: 4-((Trimethylsilyl)ethynyl)phenol
Purity: 95+%
Packaging: 1g
Price: $202
Updated: 2021/12/16

Synthonix

Product number: T54814
Product name: 4-((Trimethylsilyl)ethynyl)phenol
Purity: 95+%
Packaging: 1g
Price: $210
Updated: 2021/12/16

AK Scientific

Product number: 4038AC
Product name: 4-((Trimethylsilyl)ethynyl)phenol
Packaging: 1g
Price: $290
Updated: 2021/12/16

AK Scientific

Product number: 4038AC
Product name: 4-((Trimethylsilyl)ethynyl)phenol
Packaging: 5g
Price: $562
Updated: 2021/12/16

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4-((Trimethylsilyl)ethynyl)phenol Chemical Properties,Usage,Production

Synthesis

540-38-5

1066-54-2

88075-18-7

The general procedure for the synthesis of (4-hydroxyphenylacetylene)trimethylsilane from 4-iodophenol and trimethylsilylacetylene was as follows: 4-iodophenol (2 g, 9.09 mmol, 1 equiv) was dissolved in 20 mL of anhydrous toluene. To this solution was sequentially added PdCl2(PPh3)2 (191.4 mg, 0.27 mmol, 0.03 eq.), copper(I) iodide (172.8 mg, 0.909 mmol, 0.1 eq.), N,N-diisopropylethylamine (1.58 mL, 9.09 mmol, 1 eq.), followed by trimethylsilylacetylene (1.28 mL. 9.09 mmol, 1 equiv). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by evaporation and the residue was purified by column chromatography (eluent: EtOAc/hexane = 1:10) to afford the target product (4-hydroxyphenylacetylene)trimethylsilane (1.73 g, quantitative yield) as a brown oil. The structure of the product was confirmed by 1H-NMR (CDCl3, 500 MHz) and 13C-NMR (CDCl3, 75 MHz): 1H-NMR δ 7.37 (2H, d, J = 8.8 Hz, Ar-H), 6.76 (2H, d, J = 8.8 Hz, Ar-H), 4.92 (1H, brs, Ar-OH), 0.24 (9H , s, -Si(CH3)3); 13C-NMR δ 155.76, 133.69, 115.49, 115.31, 105.02, 92.50, 0.05.

References

[1] Chemical Communications, 2009, # 39, p. 5832 - 5834
[2] Angewandte Chemie - International Edition, 2012, vol. 51, # 37, p. 9311 - 9316
[3] Angew. Chem., 2012, vol. 124, # 37, p. 9445 - 9450,6
[4] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 4, p. 1247 - 1249
[5] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2015, vol. 70, # 9, p. 637 - 641

4-((Trimethylsilyl)ethynyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((Trimethylsilyl)ethynyl)phenol Suppliers

China 36 India 1 United States 6 Global 43

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88075-18-7, 4-((Trimethylsilyl)ethynyl)phenolRelated Search:

4-((Trimethylsilyl)ethynyl)phenol

4-[2-(TriMethylsilyl)ethynyl]-phenol

185664

Phenol, 4-[2-(trimethylsilyl)ethynyl]-

4-((Trimethylsilyl)ethynyl)phenol - [T54814]

88075-18-7