Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate

Product Name: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
CAS No.: 878650-31-8
Chemical Name: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
Synonyms: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate;4-Pyrimidinecarboxylic acid, 2,6-dichloro-5-methoxy-, methyl ester
CBNumber: CB42693257
Molecular Formula: C7H6Cl2N2O3
Formula Weight: 237.04
MOL File: 878650-31-8.mol

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Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 3999AC
Product name: Methyl2,6-dichloro-5-methoxypyrimidine-4-carboxylate
Packaging: 100mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: 3999AC
Product name: Methyl2,6-dichloro-5-methoxypyrimidine-4-carboxylate
Packaging: 250mg
Price: $259
Updated: 2021/12/16

Matrix Scientific

Product number: 096040
Product name: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $416
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0369121
Product name: METHYL-2,6-DICHLORO-5-METHOXYPYRIMIDINE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $500.59
Updated: 2021/12/16

Matrix Scientific

Product number: 096040
Product name: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
Purity: 95+%
Packaging: 1g
Price: $924
Updated: 2021/12/16

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Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate Chemical Properties,Usage,Production

Synthesis

67-56-1

1446253-05-9

878650-31-8

Example 5 Preparation of methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate: 2,6-dichloro-5-methoxypyrimidine-4-carboxaldehyde (50 g, 0.24 mol) was dissolved in a solvent mixture of methanol (1 L) and water (60 mL). Sodium bicarbonate (400 g) was added to this solution. A methanol/water (600 mL, v/v=9:1) solution of 2M bromine (192 g, 1.2 mol) was slowly added dropwise to the pyrimidine solution over a period of 45 min at 0°C while maintaining stirring. After the dropwise addition was completed, stirring was continued at the same temperature for 1 hour. Subsequently, the reaction mixture was warmed to room temperature and stirred for 4 hours. Upon completion of the reaction, the mixture was slowly poured into a mixture containing crushed ice (2 L), sodium bisulfite (50 g) and sodium chloride (200 g). The product was extracted with ethyl acetate (1L x 2), the organic layers were combined and dried over anhydrous sodium sulfate and filtered. The solvent was removed by concentration under reduced pressure to give a viscous mass, which was left to cure to give methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate (50.8 g, 87% yield): ESIMS m/z 238 ([M+H]+).

References

[1] Patent: US2014/274703, 2014, A1. Location in patent: Paragraph 0197; 0198
[2] Patent: US2014/274701, 2014, A1. Location in patent: Paragraph 0156; 0157
[3] Patent: US2014/274696, 2014, A1. Location in patent: Paragraph 0238; 0239
[4] Patent: WO2013/102111, 2013, A1. Location in patent: Page/Page column 23

Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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878650-31-8, Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylateRelated Search:

Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate

4-Pyrimidinecarboxylic acid, 2,6-dichloro-5-methoxy-, methyl ester

878650-31-8

C7H6Cl2N2O3