Synthesis
ChemicalBook > CAS DataBase List > 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE

4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE

Synthesis
Product Name
4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE
CAS No.
1682-20-8
Chemical Name
4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE
Synonyms
4-AMINOTETRAFLUOROPYRIDINE;4-AMino-2,3,5,6-terafluoropyridine;2,3,5,6-tetrafluoro-4-pyridinamine;4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE;4-Pyridinamine, 2,3,5,6-tetrafluoro-;4-AMINO-2,3,5,6-TETRAFLUORROPYRIDINE;2,3,5,6-Tetrafluoro-pyridin-4-ylamine;4-Amino-2,3,5,6-tetrafluoropyridine >4-Amino-2,3,5,6-tetrafluoropyridine 98%;4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE ISO 9001：2015 REACH
CBNumber
CB4269375
Molecular Formula
C5H2F4N2
Formula Weight
166.08
MOL File
1682-20-8.mol
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4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE Property

Melting point:
85-87 °C (lit.)
Boiling point:
85-86 °C
Density 
1.631±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
-3.11±0.10(Predicted)
color 
White to Light yellow to Light orange
BRN 
475870
InChI
InChI=1S/C5H2F4N2/c6-1-3(10)2(7)5(9)11-4(1)8/h(H2,10,11)
InChIKey
PLVFNMQHMRRBAA-UHFFFAOYSA-N
SMILES
C1(F)=NC(F)=C(F)C(N)=C1F
CAS DataBase Reference
1682-20-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29333990
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
300624
Product name
4-Amino-2,3,5,6-tetrafluoropyridine
Purity
98%
Packaging
1g
Price
$25.26
Updated
2025/07/31
TCI Chemical
Product number
A1546
Product name
4-Amino-2,3,5,6-tetrafluoropyridine
Purity
>97.0%(GC)
Packaging
1g
Price
$36
Updated
2025/07/31
TRC
Product number
A630263
Product name
4-Amino-2,3,5,6-tetrafluoropyridine
Packaging
100mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
PC5620
Product name
4-Aminotetrafluoropyridine
Purity
98%
Packaging
1g
Price
$10
Updated
2021/12/16
AK Scientific
Product number
J94418
Product name
4-Amino-2,3,5,6-tetrafluoropyridine
Packaging
1g
Price
$11
Updated
2021/12/16
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4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE Chemical Properties,Usage,Production

Synthesis

In principle, ammonia could be used to allow indirect replacement of fluorine by hydrogen. Workers in this laboratory showed that pentafluoropyridine reacted with ammonia giving 4-aminotetrafluoropyridine.

Chemical Properties

white to light yellow crystal

Uses

4-Amino-2,3,5,6-tetrafluoropyridine is formed as C-H ′insertion′ product during reaction with 4-azido-2,3,5,6-tetrafluoropyridine.

General Description

4-Amino-2,3,5,6-tetrafluoropyridine is formed as C-H ′insertion′ product during reaction with 4-azido-2,3,5,6-tetrafluoropyridine.

References

[1] Journal of Fluorine Chemistry, 1996, vol. 81, # 1, p. 39 - 42
[2] Journal of the American Chemical Society, 2017, vol. 139, # 37, p. 13092 - 13101
[3] Oriental Journal of Chemistry, 2016, vol. 32, # 4, p. 1799 - 1813
[4] Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 12, p. 2267 - 2272
[5] Zhurnal Organicheskoi Khimii, 1988, vol. 24, # 12, p. 2513 - 2518

4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

4-Bromo-2,3,5,6-tetrafluoropyridine
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4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE Suppliers

Americas 1 China 78 Europe 1 France 1 Germany 4 India 3 Italy 1 Japan 2 Russia 1 Switzerland 1 United Kingdom 14 United States 27 Global 134
Nanjing Lynsci Chemical Co., Ltd
Tel
+86-025-83208253 +86-13851694729
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0086-25-83208253
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layefe@163.com
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China
ProdList
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62
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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INTATRADE GmbH
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+49 3493/605464
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+49 3493/605470
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sales@intatrade.de
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Germany
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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China
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24529
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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86-027-87531808
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sales@chemwish.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
ProdList
18207
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66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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+86-21-54098501
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+86-21-54096319
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sales@sinch.com.cn
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China
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
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sales@chemreagents.com
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United States
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View Lastest Price from 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE 1682-20-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Henan Aochuang Chemical Co.,Ltd.
Product
4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE 1682-20-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09
Career Henan Chemical Co
Product
4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE 1682-20-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-99.9%
Supply Ability
200kg
Release date
2020-01-12

1682-20-8, 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINERelated Search:

2,3,4,5,6-Pentafluoroaniline 4-Amino-3,5-dichloro-2,6-difluoropyridine 4-(DIMETHYLAMINO)-2,3,5,6-TETRAFLUOROPYRIDINE 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE 2,3,5,6-Tetrafluoropyridine 2,3,5,6-TETRAFLUORO-4-NITROPYRIDINE 2,3,5,6-TETRAFLUORO-4-HYDRAZINOPYRIDINE N-[(4-FLUOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE 4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-{[2-(TRIFLUOROMETHYL)PHENYL]SULFONYL}PIPERAZINE-1-CARBOXAMIDE 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[2-(TRIFLUOROMETHYL)PHENYL]HYDRAZINECARBOXAMIDE 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[3-(TRIFLUOROMETHYL)PHENYL]HYDRAZINECARBOXAMIDE N-[2-CHLORO-5-(TRIFLUOROMETHYL)PHENYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE N-{[2-CHLORO-5-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE N-[(3,4-DICHLOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE 4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-{[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}PIPERAZINE-1-CARBOXAMIDE N-[(3,5-DICHLOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[4-(TRIFLUOROMETHOXY)PHENYL]HYDRAZINECARBOTHIOAMIDE 2-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINECARBOXAMIDE

  • 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE
  • 4-AMINO-2,3,5,6-TETRAFLUORROPYRIDINE
  • 4-AMINOTETRAFLUOROPYRIDINE
  • 2,3,5,6-Tetrafluoro-pyridin-4-ylamine
  • 4-AMino-2,3,5,6-terafluoropyridine
  • 4-Amino-2,3,5,6-tetrafluoropyridine 98%
  • 4-Pyridinamine, 2,3,5,6-tetrafluoro-
  • 2,3,5,6-tetrafluoro-4-pyridinamine
  • 4-Amino-2,3,5,6-tetrafluoropyridine &gt
  • 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE ISO 9001：2015 REACH
  • 1682-20-8
  • C5H2F4N2
  • AMINE
  • Halopyridines
  • Fluoropyridines
  • Building Blocks
  • C5
  • Heterocyclic Building Blocks
  • Pyridines
  • Fluoropyridines
  • Halopyridines
  • C5
  • Heterocyclic Building Blocks
  • Pyridines
  • Pyridine
  • Heterocyclic Compounds
  • Building Blocks
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Heterocyclic Building Blocks
  • Heterocyclic Fluorinated Building Blocks
  • Other Fluorinated Heterocycles