ChemicalBook > CAS DataBase List > (αR,βS)-rel-Bedaquiline
(αR,βS)-rel-Bedaquiline
- Product Name
- (αR,βS)-rel-Bedaquiline
- CAS No.
- 654653-93-7
- Chemical Name
- (αR,βS)-rel-Bedaquiline
- Synonyms
- Glycerol Impurity 108;Bedaquinoline impurity 15;Bedaquiline (1R,2S)Isomer;(AlphaR,BetaS)-rel-Bedaquiline;Bedaquiline Fumarate Impurity 40;cis-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol;(αR,βS)-rel-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol;(1R,2S)-rac-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol;3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αR,βS)-rel-
- CBNumber
- CB42694663
- Molecular Formula
- C32H31BrN2O2
- Formula Weight
- 555.5
- MOL File
- 654653-93-7.mol
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(αR,βS)-rel-Bedaquiline Property
- Melting point:
- >180°C (dec.)
- Boiling point:
- 702.7±60.0 °C(Predicted)
- Density
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 13.05±0.29(Predicted)
- form
- Solid
- color
- Off-White to Pale Yellow
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N-Bromosuccinimide Price
TRC
- Product number
- B119555
- Product name
- (αR,βS)-rel-Bedaquiline
- Packaging
- 10mg
- Price
- $130
- Updated
- 2021/12/16
TRC
- Product number
- B119555
- Product name
- (αR,βS)-rel-Bedaquiline
- Packaging
- 25mg
- Price
- $250
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 49651
- Product name
- (αR,βS)-rel-Bedaquiline
- Packaging
- 50mg
- Price
- $2200
- Updated
- 2021/12/16
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(αR,βS)-rel-Bedaquiline Chemical Properties,Usage,Production
Chemical Properties
Off-white Solid
Uses
(αR,βS)-rel-Bedaquiline is a promising diarylquinoline candidate in clinical development for the treatment of tuberculosis. (αR,βS)-rel-Bedaquiline inhibits mycobacterial ATP synthase and displays high activity against both drug-susceptible and multidrug-resistant strains of Mycobacterium tuberculosis.
Definition
ChEBI: Bedaquiline is a quinoline-based antimycobacterial drug used (as its fumarate salt) for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria. It has a role as an antitubercular agent and an ATP synthase inhibitor. It is a member of quinolines, a member of naphthalenes, an organobromine compound, an aromatic ether, a tertiary alcohol and a tertiary amino compound. It is a conjugate base of a bedaquiline(2+).
(αR,βS)-rel-Bedaquiline Preparation Products And Raw materials
Raw materials
Preparation Products
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