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NF449

Product Name
NF449
CAS No.
627034-85-9
Chemical Name
NF449
Synonyms
NF449 octasodium;NF449 Sodium Salt
CBNumber
CB42696122
Molecular Formula
C41H32N6O29S8
Formula Weight
1329.23558
MOL File
627034-85-9.mol
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NF449 Property

storage temp. 
Store at -20°C
solubility 
Soluble in H2O
form 
crystalline solid
color 
White to off-white
Water Solubility 
Soluble to 50 mM in water with gentle warming
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
480420
Product name
NF449-CAS389142-38-5-Calbiochem
Purity
ApotentGsα-subunit-selectiveG-proteinantagonist.
Packaging
10mg
Price
$294
Updated
2023/01/07
Cayman Chemical
Product number
13324
Product name
NF449 (sodium salt)
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
13324
Product name
NF449 (sodium salt)
Purity
≥95%
Packaging
5mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
13324
Product name
NF449 (sodium salt)
Purity
≥95%
Packaging
10mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
13324
Product name
NF449 (sodium salt)
Purity
≥95%
Packaging
50mg
Price
$704
Updated
2024/03/01
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NF449 Chemical Properties,Usage,Production

Uses

NF449 is a known P2X1 receptor antagonist used to regulate the intravascular platelet aggregation commonly seen in systematic thromboembolism.

Biological Activity

nf 449 is a potent purinergic receptor antagonist that displays high selectivity for p2x1. the p2x1 ion channel is activated by atp among the three p2 receptor subtypes present on blood platelets.

in vitro

the interaction of the a1-adenosine receptor with its cognate g proteins (gi/go) disrupted by nf503 and nf449 at concentrations that are >30- fold higher than those required for uncoupling of b-adrenergic receptor/gs tandems; similarly, the compounds barely affected the angiotensin ii type-1 receptor . thus, nf503 and nf449 achieve essential criteria for gsa-selective antagonists. the observations demonstrate that subtype-selective g protein inhibition is feasible[1]. inhibited 5-triphosphate-induced shape change in treatment of washed human platelets with apyrase to abolish desensitization of the p2x1 receptor. the calcium rise mediated by the p2y1 receptor was also antagonized by nf449, but with lower potency. in contrast, nf449 was a very weak antagonist of inhibiting adenylyl cyclase activity mediated by p2y12. selective blockade of the p2x1 receptor with nf449 led to decreased collagen-induced aggregation. therefore, a role of this receptor in platelet activation induced by collagen was confirmed [2]. so far, characterize nf449 as the most potent and selective antagonist of receptors (the p2x1 subunit such as the p2x1 homomer and the p2x1c5 heteromer) [3].

in vivo

intravenous injection of 10 mg/kg nf449 into mice exhibited selective inhibition of the p2x1 receptor and reduced intravascular platelet aggregation in a model of systemic thromboembolism without prolongation of the bleeding time. at a higher dose (50 mg/kg), nf449 blocked the three platelet p2 receptors. this, compared with mice injected with saline, led to a further reduction in platelet consumption. nf449 also decreased dose-dependently the size of thrombi formed after laser-induced injury of mesenteric arterioles. overall, our results indicate that nf449 constitutes a new agent to investigate the functions of the p2x1 receptor and could be a starting compound in the investigation for new antithrombotic drugs targeting the platelet tp2 receptors [2].

IC 50

0.28 nm for rp2x1

storage

Room temperature

References

[1] hohenegger m, waldhoer m, beindl w, bing b, kreimeyer a, nickel p, nanoff c, freissmuth m. gsalpha-selective g protein antagonists. proc natl acad sci u s a. 1998 jan 6;95(1):346-51.
[2] hechler b, magnenat s, zighetti ml, kassack mu, ullmann h, cazenave jp, evans r, cattaneo m, gachet c. inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet p2 receptors with increasing doses of nf449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt]. j pharmacol exp ther. 2005 jul;314(1):232-43. epub 2005 mar 25.
[3]. rettinger j, braun k, hochmann h, kassack mu, ullmann h, nickel p, schmalzing g, lambrecht g. profiling at recombinant homomeric and heteromeric rat p2x receptors identifies the suramin analogue nf449 as a highly potent p2x1 receptor antagonist. neuropharmacology. 2005 mar;48 (3):461-8.

NF449 Preparation Products And Raw materials

Raw materials

Preparation Products

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NF449 Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Shanghai TaoSu Biochemical Technology Co., Ltd.
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021-33632979
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021-34692979
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info@tsbiochem.com
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China
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Pharmacodia (Beijing) Co.,Ltd
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+86-400-851-9921
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+86-10-82826195
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sales@pharmacodia.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Amadis Chemical Company Limited
Tel
571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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131957
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Lynnchem
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86-(0)29-85992781 17792393971
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info@lynnchem.com
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China
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4587
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Novachemistry
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44-20819178-90 02081917890
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(0)2080432064
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United Kingdom
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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Guangzhou Younan Technology Co., Ltd
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020-82000279 18988968278
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QQ:3283937693
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sales@ubiochem.com
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China
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627034-85-9, NF449Related Search:


  • NF449 Sodium Salt
  • NF449 octasodium
  • 627034-85-9
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