1-Methyl-1H-pyrazol-4-ol
- Product Name
- 1-Methyl-1H-pyrazol-4-ol
- CAS No.
- 78242-20-3
- Chemical Name
- 1-Methyl-1H-pyrazol-4-ol
- Synonyms
- 1-methylpyrazol-4-ol;1-Methyl-1H-pyrazol-4-ol;1-methyl-1H-pyrazole-4-ol;1H-Pyrazol-4-ol, 1-methyl-;4-Hydroxy-1-methyl-1H-pyrazole;1-METHYL-1H-PYRAZOL-4-OL(WXC09189)
- CBNumber
- CB42696399
- Molecular Formula
- C4H6N2O
- Formula Weight
- 98.1
- MOL File
- 78242-20-3.mol
1-Methyl-1H-pyrazol-4-ol Property
- Boiling point:
- 217.7±13.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.19±0.14(Predicted)
- form
- solid
- color
- Cream
Safety
- HS Code
- 2933119000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B497158
- Product name
- 1-methyl-1H-pyrazol-4-ol
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- OR301025
- Product name
- 4-Hydroxy-1-methyl-1H-pyrazole
- Purity
- 98%
- Packaging
- 250mg
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 4H01-1-29
- Product name
- 1-Methyl-1H-pyrazol-4-ol
- Purity
- 95%
- Packaging
- 250mg
- Price
- $103
- Updated
- 2021/12/16
- Product number
- OR301025
- Product name
- 4-Hydroxy-1-methyl-1H-pyrazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $232
- Updated
- 2021/12/16
- Product number
- 4H01-1-29
- Product name
- 1-Methyl-1H-pyrazol-4-ol
- Purity
- 95%
- Packaging
- 1g
- Price
- $256
- Updated
- 2021/12/16
1-Methyl-1H-pyrazol-4-ol Chemical Properties,Usage,Production
Uses
1-Methyl-1H-pyrazol-4-ol is used as a storage and transport stabiliser for polymerised compounds and as an intermediate in the preparation of pyrazole herbicides (1-methyl-5hydroxypyrazole).
Synthesis
761446-44-0
78242-20-3
General procedure for the synthesis of 1-methyl-4-hydroxy-1H-pyrazole from 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole: To 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1.0 g, 120.2 mmol) was added slowly, under the condition of 0 °C (ice bath cooling), to a 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole ( 25.0 g, 120.2 mmol) in tetrahydrofuran solution (600.9 mL, 0.2 M) was slowly added to aqueous sodium hydroxide solution (80.1 mL, 3 M, 240.3 mmol) followed by hydrogen peroxide (27.3 mL, 240.3 mmol). The reaction mixture was stirred at 0-25°C for 3 hours. After completion of the reaction, the reaction mixture was neutralized in a small heart with 12N hydrochloric acid (18.6 mL) and diluted with a solvent mixture of dichloromethane and methanol (90:10, 200 mL). The aqueous layer was extracted with a solvent mixture of dichloromethane and methanol (90:10, 3 x 200 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography to afford the target product 1-methyl-4-hydroxy-1H-pyrazole.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 49, p. 4587 - 4590
[2] Patent: WO2016/11930, 2016, A1. Location in patent: Page/Page column 138
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1370 - 1387
1-Methyl-1H-pyrazol-4-ol Preparation Products And Raw materials
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