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Platencin

Product Name
Platencin
CAS No.
869898-86-2
Chemical Name
Platencin
Synonyms
Platencin;Benzoic acid, 3-[[3-[(2S,4aS,8S,8aR)-1,3,4,7,8,8a-hexahydro-8-methyl-3-methylene-7-oxo-2H-2,4a-ethanonaphthalen-8-yl]-1-oxopropyl]amino]-2,4-dihydroxy-
CBNumber
CB42703754
Molecular Formula
C24H27NO6
Formula Weight
425.474
MOL File
869898-86-2.mol
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Platencin Property

Boiling point:
670.1±55.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form 
A solid
pka
2.14±0.13(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13264
Product name
Platencin
Purity
≥99%
Packaging
100μg
Price
$396
Updated
2024/03/01
Cayman Chemical
Product number
13264
Product name
Platencin
Purity
≥99%
Packaging
500μg
Price
$1184
Updated
2024/03/01
TRC
Product number
P578203
Product name
Platencin
Packaging
10μg
Price
$140
Updated
2021/12/16
Usbiological
Product number
P4262
Product name
Platencin
Packaging
100ug
Price
$582
Updated
2021/12/16
Usbiological
Product number
462736
Product name
Platencin
Packaging
100μg
Price
$638
Updated
2021/12/16
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Platencin Chemical Properties,Usage,Production

Description

Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.

Uses

Platencin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Platencin is more potent than its analogue, platensimycin. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, b-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF.

Uses

Platencin is a potent antibiotic that targets FabF and FabH proteins.

Definition

ChEBI: Platencin is a monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the polycyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase. It has a role as an antibacterial agent, an antimicrobial agent, an EC 2.3.1.85 (fatty acid synthase) inhibitor and a bacterial metabolite. It is a cyclic ketone, a polycyclic cage, a dihydroxybenzoic acid, a monocarboxylic acid amide and an aromatic amide. It is a conjugate acid of a platencin(1-).

Enzyme inhibitor

This antibiotic (FW = 425.2 g/mol; CAS 869898-86-2; Soluble in ethanol, methanol, DMF or DMSO) inhibits both Staphylococcus aureus b-ketoacyl- [acyl-carrier-protein] synthases II and III, with IC50 values of 1.95 and 3.91 μg/mL, respectively. Platencin exhibits strong, broad-spectrum, Grampositive antibacterial activity to key antibiotic resistant strains, including methicillin-resistant Staphylococcus aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococcus faecium, without evidence of toxicity in humans.

Platencin Preparation Products And Raw materials

Raw materials

Preparation Products

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Platencin Suppliers

Lynnchem
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869898-86-2, PlatencinRelated Search:


  • Platencin
  • Benzoic acid, 3-[[3-[(2S,4aS,8S,8aR)-1,3,4,7,8,8a-hexahydro-8-methyl-3-methylene-7-oxo-2H-2,4a-ethanonaphthalen-8-yl]-1-oxopropyl]amino]-2,4-dihydroxy-
  • 869898-86-2