ChemicalBook > CAS DataBase List > CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)

CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)

Product Name
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
CAS No.
1092776-63-0
Chemical Name
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
Synonyms
IT1t dihydrochloride;IT1t (hydrochloride);IT1t dihydrochloride, 10 mM in DMSO;IT1t dihydrochloride,IT-1t dihydrochloride;N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride;CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1;CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
CBNumber
CB42705990
Molecular Formula
C21H35ClN4S2
Formula Weight
443.11
MOL File
1092776-63-0.mol
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CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Property

Melting point:
>187° (dec.)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28434
Product name
IT1t (hydrochloride)
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
28434
Product name
IT1t (hydrochloride)
Packaging
25mg
Price
$459
Updated
2024/03/01
Cayman Chemical
Product number
28434
Product name
IT1t (hydrochloride)
Packaging
10mg
Price
$195
Updated
2024/03/01
Tocris
Product number
4596
Product name
IT1tdihydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$195
Updated
2021/12/16
Tocris
Product number
4596
Product name
IT1tdihydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$818
Updated
2021/12/16
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CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Chemical Properties,Usage,Production

Description

IT1t is a chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist (IC50s = 8 and 11 nM for the human and rat receptors, respectively). It is selective for CXCR4 over human ether-a-go-go-related gene potassium channels (hERG/Kv11.1; IC50 = 13,240 nM). IT1t inhibits calcium mobilization induced by chemokine (C-X-C-motif) ligand 12 (CXCL12) in CEM cells (IC50 = 1.1 nM) and decreases CXCL12-induced migration of Jurkat cells (IC50 = 79.1 nM). It inhibits replication of the HIV-1 strain NL4-3 in MT-4 cells and isolated human peripheral blood mononuclear cells (PBMCs) stimulated with phytohemagglutinin (PHA; IC50s = 14.2 and 19 nM, respectively). IT1t (20 μM) reduces tumor growth in an MDA-MB-231-B zebrafish xenograft model.

Uses

N,N''-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl Ester Dihydrochloride is a potent CXCR4 antagonist. It also exhibits anti-viral activity against HIV.

in vivo

IT1t reduces the formation of TNBC early metastases in the zebrafish xenograft model. Tumor cell invasion at the metastatic site is effectively reduced upon CXCR4 silencing (Fig. 7B), similar to the antagonist IT1t [3].

IC 50

CXCL12/CXCR4: 2.1 nM (IC50); HIV-1 (X4): 14.2 nM (IC50, in MT-4 cells); HIV-1 (X4): 19 nM (IC50, in PBMCs)

storage

Store at +4°C

References

[1]. thoma g, streiff mb, kovarik j, et al. orally bioavailable isothioureas block function of the chemokine receptor cxcr4 in vitro and in vivo. j med chem, 2008, 51(24): 7915-7920.

CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Preparation Products And Raw materials

Raw materials

Preparation Products

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CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Suppliers

China 50 United Kingdom 1 United States 9 Global 60
Tianjin Anhao Biological Technology Co., Ltd.
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Shanghai Lollane Biological Technology Co.,Ltd.
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Beijing Jin Ming Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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1092776-63-0, CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)Related Search:


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  • IT1t dihydrochloride
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