CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
- Product Name
- CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
- CAS No.
- 1092776-63-0
- Chemical Name
- CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
- Synonyms
- IT1t dihydrochloride;IT1t (hydrochloride);IT1t dihydrochloride,IT-1t dihydrochloride;N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride;CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1;CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2);CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
- CBNumber
- CB42705990
- Molecular Formula
- C21H35ClN4S2
- Formula Weight
- 443.11
- MOL File
- 1092776-63-0.mol
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Property
- Melting point:
- >187° (dec.)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
N-Bromosuccinimide Price
- Product number
- 28434
- Product name
- IT1t (hydrochloride)
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 28434
- Product name
- IT1t (hydrochloride)
- Packaging
- 25mg
- Price
- $459
- Updated
- 2024/03/01
- Product number
- 28434
- Product name
- IT1t (hydrochloride)
- Packaging
- 10mg
- Price
- $195
- Updated
- 2024/03/01
- Product number
- 4596
- Product name
- IT1tdihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 4596
- Product name
- IT1tdihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $818
- Updated
- 2021/12/16
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Chemical Properties,Usage,Production
Description
IT1t is a chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist (IC50s = 8 and 11 nM for the human and rat receptors, respectively). It is selective for CXCR4 over human ether-a-go-go-related gene potassium channels (hERG/Kv11.1; IC50 = 13,240 nM). IT1t inhibits calcium mobilization induced by chemokine (C-X-C-motif) ligand 12 (CXCL12) in CEM cells (IC50 = 1.1 nM) and decreases CXCL12-induced migration of Jurkat cells (IC50 = 79.1 nM). It inhibits replication of the HIV-1 strain NL4-3 in MT-4 cells and isolated human peripheral blood mononuclear cells (PBMCs) stimulated with phytohemagglutinin (PHA; IC50s = 14.2 and 19 nM, respectively). IT1t (20 μM) reduces tumor growth in an MDA-MB-231-B zebrafish xenograft model.
Uses
N,N''-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl Ester Dihydrochloride is a potent CXCR4 antagonist. It also exhibits anti-viral activity against HIV.
storage
Store at +4°C
References
[1]. thoma g, streiff mb, kovarik j, et al. orally bioavailable isothioureas block function of the chemokine receptor cxcr4 in vitro and in vivo. j med chem, 2008, 51(24): 7915-7920.
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Preparation Products And Raw materials
Raw materials
Preparation Products
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77