N1-(2,2,6,6-tetraMethylpiperidin-4-yl)-N2-p-tolyloxalaMide
- Product Name
- N1-(2,2,6,6-tetraMethylpiperidin-4-yl)-N2-p-tolyloxalaMide
- CAS No.
- 144217-65-2
- Chemical Name
- N1-(2,2,6,6-tetraMethylpiperidin-4-yl)-N2-p-tolyloxalaMide
- Synonyms
- YYA-021;CS-2313;YYA-021 (YYA 021;N1-(2,2,6,6-tetraMethylpiperidin-4-yl)-N2-p-tolyloxalaMide;N-(2,2,6,6-Tetramethyl-piperidin-4-yl)-N'-p-tolyl-oxalamide;N'-(4-Methylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide;Human immunodeficiency virus,YYA021,inhibit,Inhibitor,YYA-021,HIV;N-(4-Methylphenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide;N1-(4-Methylphenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)ethanediamide;Ethanediamide, N1-(4-methylphenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-
- CBNumber
- CB42707934
- Molecular Formula
- C18H27N3O2
- Formula Weight
- 317.43
- MOL File
- 144217-65-2.mol
N1-(2,2,6,6-tetraMethylpiperidin-4-yl)-N2-p-tolyloxalaMide Property
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Limited solubility
- form
- Powder
- pka
- 11.61±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22915
- Product name
- YYA-021
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 22915
- Product name
- YYA-021
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $95
- Updated
- 2024/03/01
- Product number
- 22915
- Product name
- YYA-021
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 22915
- Product name
- YYA-021
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- Y110000
- Product name
- YYA-021
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
N1-(2,2,6,6-tetraMethylpiperidin-4-yl)-N2-p-tolyloxalaMide Chemical Properties,Usage,Production
Uses
YYA-021 is a small molecule CD4 mimic HIV entry inhibitor that can suppress competitively the interaction between an HIV-1 envelope glycoprotein gp120 and a cellular surface protein CD4.
Biological Activity
yya-021 is a small-molecule cd4 mimic that inhibits hiv entry [1].cd4 is a cell surface protein. the entry of human immunodeficiency virus type 1 (hiv-1) into target cells is initiated by the interaction of cd4 and viral envelope glycoprotein gp120. cd4 mimic inhibits the interaction between gp120 and cd4 and then inhibits hiv entry [1].yya-021 is a small-molecule cd4 mimic that inhibits hiv entry. yya-021 competitively inhibited gp120-cd4 interaction [1]. in tzm-bl cells infected with simian-human immunodeficiency virus isolate mna (shiv mna) or hiv-1 mna pseudotyped viruses, yya-021 inhibited the entry of envs of shiv mna and hiv-1. kd-247 (the anti-v3 loop mab, 50 μg) caused 50% neutralization of hiv-1 mna. however, in the presence of 20 μm of yya-021, kd-247 (<0.05 μg) caused 50% neutralization of hiv-1 mna, which suggested that the synergistic neutralization effect of yya-021 and kd-247. in the presence of yya-021, shiv mna became more sensitive to igg [2].in jcl:sd rats, the maximum tolerated dose of yya-021.hcl was 2.5 mg. when administrated by tail vein injection, yya-021 exhibited widespread tissue distribution due to its hydrophobicity. in a rhesus macaque, the maximum tolerated dose of yya-021.hcl was 35.3 mg [1].
target
gp120-CD4 interaction
References
[1]. hashimoto c, narumi t, otsuki h, et al. a cd4 mimic as an hiv entry inhibitor: pharmacokinetics. bioorg med chem, 2013, 21(24): 7884-7889.
[2]. otsuki h, hishiki t, miura t, et al. generation of a replication-competent simian-human immunodeficiency virus, the neutralization sensitivity of which can be enhanced in the presence of a small-molecule cd4 mimic. j gen virol, 2013, 94(pt 12): 2710-2716.
N1-(2,2,6,6-tetraMethylpiperidin-4-yl)-N2-p-tolyloxalaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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