tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

Product Name: tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
CAS No.: 1228014-35-4
Chemical Name: tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Synonyms: 1-Boc-4-bromo-7-azaindole;tert-butyl 4-bromopyrrolo[2,3-b]pyridine-1-carboxylate;tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate;4-Bromo-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester;1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 4-bromo-, 1,1-dimethylethyl ester
CBNumber: CB42708113
Molecular Formula: C12H13BrN2O2
Formula Weight: 297.15
MOL File: 1228014-35-4.mol

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tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Property

Boiling point:: 376.7±45.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.16±0.30(Predicted)
Appearance: orange oil

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B701913
Product name: tert-Butyl4-Bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 4386AA
Product name: tert-Butyl4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Packaging: 5g
Price: $860
Updated: 2021/12/16

AK Scientific

Product number: 4386AA
Product name: tert-Butyl4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Packaging: 250mg
Price: $158
Updated: 2021/12/16

Ambeed

Product number: A126162
Product name: tert-Butyl4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Purity: 96%
Packaging: 5g
Price: $202
Updated: 2021/12/16

Ambeed

Product number: A126162
Product name: tert-Butyl4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Purity: 96%
Packaging: 1g
Price: $202
Updated: 2021/12/16

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tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

348640-06-2

1228014-35-4

4-Bromo-1H-pyrrolo[2,3-b]pyridine (XCI) (5 g, 25.4 mmol, 1 eq.) was used as a starting material, which was dissolved in dichloromethane (DCM) (100 mL), 4-dimethylaminopyridine (DMAP) (311 mg, 2.55 mmol, 0.1 eq.) and triethylamine (TEA) (5.3 mL) were added. Di-tert-butyl dicarbonate (Boc2O) (7.2 mL, 31 mmol, 1.2 eq.) was slowly added to the reaction mixture at 0 °C. The reaction system was gradually warmed to room temperature and stirred continuously for 2 hours. Upon completion of the reaction, it was quenched by addition of water (100 mL) and extracted twice with dichloromethane (DCM). The organic phases were combined and concentrated under reduced pressure to remove the solvent to afford tert-butyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (XCII) as a colorless oil (6.95 g, 23.4 mmol, 92.1% yield). The product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 1.60 (s, 9H), 6.50 (d, J = 4 Hz, 1H), 7.31 (d, J = 5.2 Hz, 1H), 7.63 (d, J = 4 Hz, 1H), 8.23 (d, J = 5.2 Hz, 1H); electrospray ionization mass spectrometry (ESIMS) analysis showed molecular ion peaks m/z 297.1 (M + H), consistent with the expected molecular formula C12H13BrN2O2.

References

[1] Patent: WO2017/24021, 2017, A1. Location in patent: Paragraph 0694; 0695
[2] Patent: WO2017/24004, 2017, A1. Location in patent: Paragraph 0676
[3] Patent: WO2017/23980, 2017, A1. Location in patent: Paragraph 0676
[4] Patent: WO2017/23996, 2017, A1. Location in patent: Paragraph 0676
[5] Patent: WO2012/101654, 2012, A2. Location in patent: Page/Page column 59

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Suppliers

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1228014-35-4, tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylateRelated Search:

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

4-Bromo-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester

1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 4-bromo-, 1,1-dimethylethyl ester

1-Boc-4-bromo-7-azaindole

tert-butyl 4-bromopyrrolo[2,3-b]pyridine-1-carboxylate

1228014-35-4