RSC 133

Product Name: RSC 133
CAS No.: 1418131-46-0
Chemical Name: RSC 133
Synonyms: RSC 133;RSC133,RSC 133;Lemborexant N1-Oxide;Reprogramming stimulating compound 133;3-[[(E)-3-(1H-indol-3-yl)prop-2-enoyl]amino]benzamide;3-[[(2E)-3-(1H-Indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide;Benzamide, 3-[[(2E)-3-(1H-indol-3-yl)-1-oxo-2-propen-1-yl]amino]-
CBNumber: CB42708850
Molecular Formula: C18H15N3O2
Formula Weight: 305.33
MOL File: 1418131-46-0.mol

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RSC 133 Property

Boiling point:: 653.7±55.0 °C(Predicted)
Density: 1.372±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 13.22±0.70(Predicted)
color: white to light brown
InChI: 1S/C18H15N3O2/c19-18(23)12-4-3-5-14(10-12)21-17(22)9-8-13-11-20-16-7-2-1-6-15(13)16/h1-11,20H,(H2,19,23)(H,21,22)/b9-8+
InChIKey: HYUDSQGICKAEGE-CMDGGOBGSA-N
SMILES: NC(C1=CC=CC(NC(/C=C/C2=CNC3=C2C=CC=C3)=O)=C1)=O

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-51/53
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1113
Product name: RSC133
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1113
Product name: RSC133
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $464
Updated: 2023/01/07

Cayman Chemical

Product number: 9001839
Product name: RSC-133
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 9001839
Product name: RSC-133
Purity: ≥95%
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 9001839
Product name: RSC-133
Purity: ≥95%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

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RSC 133 Chemical Properties,Usage,Production

Description

RSC-133 is an indole compound that promotes the reprogramming of human somatic cells to pluripotent stem cells. Specifically, when used at 10 μM with four standard reprogramming factors, it increases the number of human foreskin fibroblasts that express the stem cell marker alkaline phosphatase. RSC-133 induces pluripotency by both down-regulating inducers of cellular senescence and inhibiting DNA methyltransferase and histone deacetylase activities.

Uses

RSC 133 is a potent chemical booster for human somatic cell reprogramming. RSC 133 facilitates the maintenance of pluripotent human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs).

References

[1] DR. JUNGWOON LEE. A Novel Small Molecule Facilitates the Reprogramming of Human Somatic Cells into a Pluripotent State and Supports the Maintenance of an Undifferentiated State of Human Pluripotent Stem Cells[J]. Angewandte Chemie International Edition, 2012, 51 50: 12509-12513. DOI: 10.1002/anie.201206691

RSC 133 Preparation Products And Raw materials

Raw materials

Preparation Products

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RSC 133 Suppliers

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1418131-46-0, RSC 133Related Search:

RSC 133

3-[[(2E)-3-(1H-Indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide

Reprogramming stimulating compound 133

3-[[(E)-3-(1H-indol-3-yl)prop-2-enoyl]amino]benzamide

Benzamide, 3-[[(2E)-3-(1H-indol-3-yl)-1-oxo-2-propen-1-yl]amino]-

RSC133,RSC 133

Lemborexant N1-Oxide

1418131-46-0