Methyl 5-iodothiophene-2-carboxylate
- Product Name
- Methyl 5-iodothiophene-2-carboxylate
- CAS No.
- 88105-22-0
- Chemical Name
- Methyl 5-iodothiophene-2-carboxylate
- Synonyms
- Methyl 5-iodothiophene-2-carboxylate;5-iodo-2-Thiophenecarboxylic acid methyl ester;5-Iodo-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 5-iodo-, methyl ester
- CBNumber
- CB42710165
- Molecular Formula
- C6H5IO2S
- Formula Weight
- 268.07
- MOL File
- 88105-22-0.mol
Methyl 5-iodothiophene-2-carboxylate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Off-white to gray Solid
Safety
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- 6H66-H-02
- Product name
- Methyl 5-iodothiophene-2-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $152
- Updated
- 2021/12/16
- Product number
- 126979
- Product name
- Methyl5-iodothiophene-2-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $684
- Updated
- 2021/12/16
- Product number
- 126979
- Product name
- Methyl5-iodothiophene-2-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $2664
- Updated
- 2021/12/16
- Product number
- CM124200
- Product name
- methyl5-iodothiophene-2-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $1256
- Updated
- 2021/12/16
- Product number
- 88105220
- Product name
- Methyl5-iodothiophene-2-carboxylate
- Packaging
- 1g
- Price
- $281.41
- Updated
- 2021/12/16
Methyl 5-iodothiophene-2-carboxylate Chemical Properties,Usage,Production
Synthesis
5380-42-7
2712-78-9
88105-22-0
Steps for the synthesis of methyl 5-iodothiophene-2-carboxylate (P-1): methyl thiophene-2-carboxylate (5.0 g, 28.7 mmol) was dissolved in 35 mL of anhydrous carbon tetrachloride under nitrogen protection. Iodine (3.65 g, 14.37 mmol) and [bis(trifluoroacetoxy)iodo]benzene (6.67 g, 15.52 mmol) were then added sequentially. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, it was diluted with the addition of dichloromethane and extracted with 10% sodium thiosulfate solution to remove unreacted iodine. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (eluent: 40% hexane/60% chloroform) to give a white solid. For further purification, the resulting solid was co-milled with pentane to remove residual feedstock, resulting in the target compound P-1 (4.8 g, 63% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.89 (s, 3H), 7.28 (d, J = 3.9 Hz, 1H), 7.45 (d, J = 3.9 Hz, 1H).
References
[1] Patent: US6274620, 2001, B1
Methyl 5-iodothiophene-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 5-iodothiophene-2-carboxylate Suppliers
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 40000
- Advantage
- 60
- Tel
- 0371-86658258
- Fax
- 0371-60996044
- info@coreychem.com
- Country
- China
- ProdList
- 10453
- Advantage
- 58
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15813
- Advantage
- 58
- Tel
- 021-4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52679
- Advantage
- 58
- Tel
- 0516-0516-88997009 18651776937
- 4164357@qq.com
- Country
- China
- ProdList
- 3204
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58