2-broMo-3-(difluoroMethoxy)pyridine

Product Name: 2-broMo-3-(difluoroMethoxy)pyridine
CAS No.: 947249-27-6
Chemical Name: 2-broMo-3-(difluoroMethoxy)pyridine
Synonyms: 2-broMo-3-(difluoroMethoxy)pyridine;Pyridine,2-bromo-3-(difluoromethoxy)-
CBNumber: CB42711566
Molecular Formula: C6H4BrF2NO
Formula Weight: 224
MOL File: 947249-27-6.mol

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2-broMo-3-(difluoroMethoxy)pyridine Property

Boiling point:: 228.2±35.0 °C(Predicted)
Density: 1.670±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.58±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C6H4BrF2NO/c7-5-4(11-6(8)9)2-1-3-10-5/h1-3,6H
InChIKey: JSKYTOQKHIJDNI-UHFFFAOYSA-N
SMILES: C1(Br)=NC=CC=C1OC(F)F

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B292485
Product name: 2-bromo-3-(difluoromethoxy)pyridine
Packaging: 50mg
Price: $110
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-B-52
Product name: 2-Bromo-3-(difluoromethoxy)pyridine
Packaging: 250mg
Price: $152
Updated: 2021/12/16

Apolloscientific

Product number: PC448004
Product name: 2-Bromo-3-(difluoromethoxy)pyridine
Purity: 95%
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Apolloscientific

Product number: PC448004
Product name: 2-Bromo-3-(difluoromethoxy)pyridine
Purity: 95%
Packaging: 1g
Price: $240
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-B-52
Product name: 2-Bromo-3-(difluoromethoxy)pyridine
Packaging: 1g
Price: $384
Updated: 2021/12/16

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2-broMo-3-(difluoroMethoxy)pyridine Chemical Properties,Usage,Production

Synthesis

6602-32-0

1895-39-2

947249-27-6

General procedure for the synthesis of 2-bromo-3-(difluoromethoxy)pyridine from 2-bromo-3-hydroxypyridine and sodium difluorochloroacetate: 2-bromo-3-hydroxypyridine (3.55 g, 20.4 mmol), sodium difluorochloroacetate (6.22 g, 40.8 mmol), and sodium hydroxide (0.90 g, 22.4 mmol) were reacted with 2-bromo-3-hydroxypyridine (3.55 g, 20.4 mmol), sodium difluorochloroacetate (6.22 g, 40.8 mmol), and sodium hydroxide (0.90 g, 22.4 mmol) in a N,N-dimethylformamide (20 mL) in N,N-dimethylformamide (20 mL) was heated and reacted at 55 °C for 111 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure. The resulting residue was partitioned between ethyl acetate (80 mL) and saturated sodium bicarbonate solution (40 mL). The organic phase was separated, washed with saturated saline (40 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography (eluent: 100:0 to 0:100 hexane-ethyl acetate gradient) to afford 2-bromo-3-(difluoromethoxy)pyridine 1.95 g (43% yield). Product characterization data: LCMS (m/z, MH+): 225.9, tR = 0.74 min; 1H NMR (CDCl3, 400 MHz) δ 8.23-8.33 (m, 1H), 7.52-7.60 (m, 1H), 7.27-7.35 (m, 1H), 6.60 (t, J = 72.4 Hz, 1H).

References

[1] Patent: US2013/210818, 2013, A1. Location in patent: Paragraph 0414
[2] Patent: WO2009/115572, 2009, A2. Location in patent: Page/Page column 125
[3] Patent: WO2012/7869, 2012, A2. Location in patent: Page/Page column 107

2-broMo-3-(difluoroMethoxy)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-broMo-3-(difluoroMethoxy)pyridine Suppliers

China 44 India 1 United Kingdom 1 United States 4 Global 50

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947249-27-6, 2-broMo-3-(difluoroMethoxy)pyridineRelated Search:

2-broMo-3-(difluoroMethoxy)pyridine

Pyridine,2-bromo-3-(difluoromethoxy)-

947249-27-6