ChemicalBook > CAS DataBase List > Dafadine-A
Dafadine-A
- Product Name
- Dafadine-A
- CAS No.
- 1065506-69-5
- Chemical Name
- Dafadine-A
- Synonyms
- CS-1223;Dafadine-A;Dafadine A >=98% (HPLC);Dafadine-A, 10 mM in DMSO;Dafadine A,Cytochrome P450,CYPs,Dafadine-A,Inhibitor,DafadineA,inhibit;4-(1-{5-[(2,6-dimethylphenoxy)methyl]-1,2-oxazole-3-carbonyl}piperidin-4-yl)pyridine;4-[1-({ 5-[(2,6-Dimethylphenoxy)methyl]-3-isoxazolyl}carbonyl)-4-piperidinyl]pyridine;Methanone, [5-[(2,6-dimethylphenoxy)methyl]-3-isoxazolyl][4-(4-pyridinyl)-1-piperidinyl]-;Dafadine-A [5-[(2,6-dimethylphenoxy) methyl]-1,2-oxazol-3-yl]-(4-pyridin-4-ylpiperidin-1-yl)methanone
- CBNumber
- CB42715625
- Molecular Formula
- C23H25N3O3
- Formula Weight
- 391.46
- MOL File
- 1065506-69-5.mol
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Dafadine-A Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0736
- Product name
- Dafadine A
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $93.9
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0736
- Product name
- Dafadine A
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $207
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-3184
- Product name
- Dafadine A
- Purity
- 98.94%
- Packaging
- 50mg
- Price
- $350
- Updated
- 2021/12/16
AK Scientific
- Product number
- SYN5016
- Product name
- Dafadine A
- Packaging
- 50mg
- Price
- $365
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3184
- Product name
- Dafadine A
- Purity
- 98.94%
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
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Dafadine-A Chemical Properties,Usage,Production
Definition
ChEBI: Dafadine A is an N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2,6-dimethylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine. It has a role as a P450 inhibitor and a geroprotector. It is a member of pyridines, a N-acylpiperidine, a member of isoxazoles, an aromatic ether and an aromatic amide.
Biological Activity
Dafadine A is a selective inhibitor of C. elegans DAF-9 cytochrome P450, a key regulator of dauer formation, developmental timing and longevity. C. elegans has four life stages. In harsh environmental conditions, nematodes can convert to the L3 stage, known as the ""non-aging"" dauer stage, in which development ceases until improved conditions are sensed. Dafadine A can induce dauer formation and increased longevity in wild-type worms raised in nonstressful conditions. Dafadine A is the only inhibitor known to robustly inhibit DAF-9 in wild-type worms. It does not inhibit DAF-12 activity. Dafadine is active in mammalian systems, inhibiting CYP27A1, the mammalian functional ortholog of DAF-9 th at oxidizes 4-cholesten-3-one to make 26-hydroxy-4-cholesten-3-one and Δ4-dafachronic acid, without inhibiting other sterol- and oxysterol-metabolizing P450s such as CYP7A1 or CYP7B1.
Dafadine-A Preparation Products And Raw materials
Raw materials
Preparation Products
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