LDN-27219
- Product Name
- LDN-27219
- CAS No.
- 312946-37-5
- Chemical Name
- LDN-27219
- Synonyms
- 184663;CS-1194;LDN-27219;LDN-27219 (LDN 27219;LDN-27219 >=98% (HPLC);LDN-27219, 10 mM in DMSO;2-({4-oxo-3,5-diphenyl-3H,4H-thieno[2,3-d]pyrimid in-2-yl}sulfanyl)acetohydrazide;2-((4-oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetohydrazide;2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-acetic acid hydrazide;Acetic acid, 2-[(3,4-dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-, hydrazide
- CBNumber
- CB42715645
- Molecular Formula
- C20H16N4O2S2
- Formula Weight
- 408.5
- MOL File
- 312946-37-5.mol
LDN-27219 Property
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 11.87±0.37(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0744
- Product name
- LDN-27219
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $107
- Updated
- 2025/07/31
- Product number
- SML0744
- Product name
- LDN-27219
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $286
- Updated
- 2025/07/31
- Product number
- 4602
- Product name
- LDN27219
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $203
- Updated
- 2021/12/16
- Product number
- 4602
- Product name
- LDN27219
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $825
- Updated
- 2021/12/16
- Product number
- L397683
- Product name
- LDN27219
- Packaging
- 2.5mg
- Price
- $220
- Updated
- 2021/12/16
LDN-27219 Chemical Properties,Usage,Production
Uses
LDN 27219 is a transglutaminase inhibitor.
Biological Activity
LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2) th at binds to the GTP binidng site of the enzyme and inhbits activity with and IC50 of 600 nM.', 'LDN-27219 is a thieno[2,3-d]pyrimidine-4-one-acylhydrazide derivative. Closed conformation of TG2 induced by LDN-27219 can be a potential therapeutic strategy for age-related vascular dysfunction and lowering blood pressure.
in vivo
LDN-27219 (0.1-2 mg/kg; i.v. once) affects vivo arterial pressure and shows larger effects on older rats[2].
| Animal Model: | 12 to 14-week-old male Wistar rats[2] |
| Dosage: | 0.1, 1 and 2 mg/kg |
| Administration: | Intravenous injection; 0.1, 1 and 2 mg/kg once |
| Result: | Dose-dependently decreased mean arterial pressure of mice. |
| Animal Model: | 12 to 14- and 35 to 40-week-old male Wistar rats |
| Dosage: | 0.1, 1 and 2 mg/kg |
| Administration: | Intravenous injection; 0.1, 1 and 2 mg/kg once |
| Result: | Decreased mean arterial pressure in old group more significant than young group. |
storage
Store at +4°C
LDN-27219 Preparation Products And Raw materials
Raw materials
Preparation Products
LDN-27219 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77