LDN-27219

Product Name: LDN-27219
CAS No.: 312946-37-5
Chemical Name: LDN-27219
Synonyms: 184663;CS-1194;LDN-27219;LDN-27219 (LDN 27219;LDN-27219 >=98% (HPLC);LDN-27219, 10 mM in DMSO;2-({4-oxo-3,5-diphenyl-3H,4H-thieno[2,3-d]pyrimid in-2-yl}sulfanyl)acetohydrazide;2-((4-oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetohydrazide;2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-acetic acid hydrazide;Acetic acid, 2-[(3,4-dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-, hydrazide
CBNumber: CB42715645
Molecular Formula: C20H16N4O2S2
Formula Weight: 408.5
MOL File: 312946-37-5.mol

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LDN-27219 Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble15mg/mL, clear
pka: 11.87±0.37(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0744
Product name: LDN-27219
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0744
Product name: LDN-27219
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $386
Updated: 2024/03/01

Tocris

Product number: 4602
Product name: LDN27219
Purity: ≥99%(HPLC)
Packaging: 10
Price: $203
Updated: 2021/12/16

Tocris

Product number: 4602
Product name: LDN27219
Purity: ≥99%(HPLC)
Packaging: 50
Price: $825
Updated: 2021/12/16

TRC

Product number: L397683
Product name: LDN27219
Packaging: 2.5mg
Price: $220
Updated: 2021/12/16

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LDN-27219 Chemical Properties,Usage,Production

Uses

LDN 27219 is a transglutaminase inhibitor.

Biological Activity

LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2) th at binds to the GTP binidng site of the enzyme and inhbits activity with and IC50 of 600 nM.', 'LDN-27219 is a thieno[2,3-d]pyrimidine-4-one-acylhydrazide derivative. Closed conformation of TG2 induced by LDN-27219 can be a potential therapeutic strategy for age-related vascular dysfunction and lowering blood pressure.

storage

Store at +4°C

LDN-27219 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN-27219 Suppliers

China 34 United Kingdom 1 United States 14 Global 49

MedChemexpress LLC

Tel: 021-58955995
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EMMX Biotechnology LLC

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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TargetMol Chemicals Inc.

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Aladdin Scientific

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United States Biological

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ApexBio Technology

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BOC Sciences

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Cayman Chemical Company

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United States Biological

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Riedel-de Haen AG

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312946-37-5, LDN-27219Related Search:

CS-1194

LDN-27219 (LDN 27219

184663

LDN-27219

2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-acetic acid hydrazide

2-((4-oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetohydrazide

Acetic acid, 2-[(3,4-dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-, hydrazide

LDN-27219 >=98% (HPLC)

2-({4-oxo-3,5-diphenyl-3H,4H-thieno[2,3-d]pyrimid in-2-yl}sulfanyl)acetohydrazide

vasodilation,smooth muscle cell,Inhibitor,rat,LDN 27219,reversible,LDN-27219,slow-binding,LDN27219,inhibit,arterial pressure

LDN-27219, 10 mM in DMSO

312946-37-5