4-Chloro-5-(trifluoromethyl)quinazoline

Product Name: 4-Chloro-5-(trifluoromethyl)quinazoline
CAS No.: 16499-63-1
Chemical Name: 4-Chloro-5-(trifluoromethyl)quinazoline
Synonyms: 4-Chloro-5-(trifluoromethyl)quinazoline;Quinazoline, 4-chloro-5-(trifluoromethyl)-;4-chloro-5-(trifluoroMethyl)-3,4-dihydroquinazoline
CBNumber: CB42717629
Molecular Formula: C9H4ClF3N2
Formula Weight: 232.59
MOL File: 16499-63-1.mol

More

Less

4-Chloro-5-(trifluoromethyl)quinazoline Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 161790
Product name: 4-Chloro-5-(trifluoromethyl)quinazoline
Purity: 95%
Packaging: 2.500g
Price: $1650
Updated: 2021/12/16

Chemenu

Product number: CM142727
Product name: 4-Chloro-5-(trifluoromethyl)quinazoline
Purity: 97%
Packaging: 5g
Price: $1683
Updated: 2021/12/16

Crysdot

Product number: CD11241447
Product name: 4-Chloro-5-(trifluoromethyl)quinazoline
Purity: 97%
Packaging: 5g
Price: $2079
Updated: 2021/12/16

Alichem

Product number: 16499631
Product name: 4-Chloro-5-(trifluoromethyl)quinazoline
Packaging: 10g
Price: $3651.5
Updated: 2021/12/16

Alichem

Product number: 16499631
Product name: 4-Chloro-5-(trifluoromethyl)quinazoline
Packaging: 25g
Price: $5360
Updated: 2021/12/16

More

Less

4-Chloro-5-(trifluoromethyl)quinazoline Chemical Properties,Usage,Production

Synthesis

436-73-7

16499-63-1

The general procedure for the synthesis of 4-chloro-5-(trifluoromethyl)quinazolin-4(3H)-one from 5-(trifluoromethyl)quinazolin-4(3H)-one was as follows: triethylamine (29.3 ml, 210 mmol) was slowly added to a mixture of phosphoryl chloride (331 g, 2.16 mol) containing intermediate 14-b (8.00 g, 37.4 mmol) at 0 °C. The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was dissolved in ethyl acetate (200 ml) and the solution was quenched by slowly pouring it into ice (200 g). After separation of the organic layer, it was washed sequentially with water (1 x 100 ml), 10% aqueous sodium bicarbonate solution (2 x 100 ml), water (1 x 100 ml) and brine (1 x 100 ml). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The residue was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (ratio tapered from 1/0 to 1/1) to afford the target product Intermediate 14 (7.97 g, 91.38% yield). The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts δppm of 7.89-8.06 (m, 1H), 8.22 (d, J=7.50 Hz, 1H), 8.31 (d, J=8.38 Hz, 1H), 9.11 (s, 1H).

References

[1] Patent: WO2016/91791, 2016, A1. Location in patent: Page/Page column 26; 27
[2] Patent: WO2016/91774, 2016, A1. Location in patent: Page/Page column 84

4-Chloro-5-(trifluoromethyl)quinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Chloro-5-(trifluoromethyl)quinazoline Suppliers

China 25 India 1 United States 2 Global 28

Carbott PharmTech Inc.

Tel: 0535-6385396
Fax: +86 (535) 638-9971
Email: info@carbottpharm.com
Country: China
ProdList: 957
Advantage: 56

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 4986
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815688 13927872512
Fax: 0751-8963795
Email: 3007421951@qq.com
Country: China
ProdList: 9939
Advantage: 58

Allfluoro pharmaceutical co. ltd.

Tel: +86-400-0216110 +86-15958047586
Fax: 0086-21-33275002
Email: sales@allfluoro.com
Country: China
ProdList: 11385
Advantage: 58

Blocksynth Pharmaceutical Technology Co.,Ltd

Tel: 0086-19817745290; +8619817745290
Email: bd@blocksynth.com
Country: China
ProdList: 5661
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9992
Advantage: 58

Zhengzhou Edward Biology Co.,Ltd

Tel: 0371-63682289 15538176268
Fax: QQ：1875164801
Email: jacschem@163.com
Country: China
ProdList: 9925
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Naiys Biological Technology Co., Ltd

Tel: 18321139117
Email: 316441092@qq.con
Country: China
ProdList: 3006
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: ET-market@chemextension.com
Country: China
ProdList: 4672
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Heze Aiding Pharmaceutical Co., Ltd

Tel: 17661365138
Email: 2845578351@qq.com
Country: China
ProdList: 7115
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Suzhou Qihang Biotechnology Co., Ltd

Tel: 18151111370
Email: 1046215251@qq.com
Country: China
ProdList: 8718
Advantage: 58

Ningbo Zhenyue Pharmaceutical Technology Co., Ltd

Tel: 19817745290
Email: bd@blocksynth.com
Country: China
ProdList: 5869
Advantage: 58

Jining Yize Pharmaceutical Technology Co., Ltd

Tel: 15192473210
Email: 302633902@qq.com
Country: China
ProdList: 4480
Advantage: 58

Jiangsu Qianyu Molecular Technology Co., Ltd

Tel: 18136353590; 18136353590
Email: 2314725130@qq.com
Country: China
ProdList: 496
Advantage: 58

Guangdong Yuanfeng Chemical Reagent Co., Ltd

Tel: 13318584237
Email: 3930831290@qq.com
Country: China
ProdList: 3722
Advantage: 58

Yulin Runtianchang Chemical Co., Ltd

Tel: 15890142075
Email: 3555133855@qq.com
Country: China
ProdList: 9850
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: +undefined18143011203
Email: info@chemextension.com
Country: China
ProdList: 42056
Advantage: 58

More

Less

View Lastest Price from 4-Chloro-5-(trifluoromethyl)quinazoline manufacturers

Career Henan Chemical Co

Product: 4-Chloro-5-(trifluoromethyl)quinazoline 16499-63-1
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

16499-63-1, 4-Chloro-5-(trifluoromethyl)quinazolineRelated Search:

4-Chloro-5-(trifluoromethyl)quinazoline

4-chloro-5-(trifluoroMethyl)-3,4-dihydroquinazoline

Quinazoline, 4-chloro-5-(trifluoromethyl)-

16499-63-1