4-Hydroxyalternariol
- Product Name
- 4-Hydroxyalternariol
- CAS No.
- 959417-21-1
- Chemical Name
- 4-Hydroxyalternariol
- Synonyms
- 4-Hydroxyalternariol;Hydroxyalternariol, 4-;Alternariol Impurity 18;3,4,7,9-tetrahydroxy-1-methylbenzo[c]chromen-6-one;3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one;6H-Dibenzo[b,d]pyran-6-one, 3,4,7,9-tetrahydroxy-1-methyl-
- CBNumber
- CB42720810
- Molecular Formula
- C14H10O6
- Formula Weight
- 274.23
- MOL File
- 959417-21-1.mol
4-Hydroxyalternariol Property
- storage temp.
- Store at -20°C
- solubility
- DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 23636
- Product name
- 4-hydroxy Alternariol
- Purity
- >95%
- Packaging
- 500μg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 23636
- Product name
- 4-hydroxy Alternariol
- Purity
- >95%
- Packaging
- 1mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 23636
- Product name
- 4-hydroxy Alternariol
- Purity
- >95%
- Packaging
- 5mg
- Price
- $931
- Updated
- 2024/03/01
- Product number
- 4375EF
- Product name
- 3,4,7,9-Tetrahydroxy-1-methylbenzo[c]chromen-6-one
- Packaging
- 5mg
- Price
- $1135
- Updated
- 2021/12/16
4-Hydroxyalternariol Chemical Properties,Usage,Production
Description
4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 μM under cell-free conditions.
Uses
4-Hydroxyalternariol is the fully demethylated tetraphenol analogue of the benzopyranone graphislactones. Hydroxyalternariol was isolated as a major co-metabolite of a graphislactone A-producing fungus. Hydroxyalternariol has not previously been available for study and no bioactivity has been reported to date.
Uses
4-Hydroxy Alternariol is a derivative of Alternariol (A575760). Alternariol is an alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks.
4-Hydroxyalternariol Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxyalternariol Suppliers
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