ChemicalBook > CAS DataBase List > ERDAFITINIB

ERDAFITINIB

Product Name
ERDAFITINIB
CAS No.
1346242-81-6
Chemical Name
ERDAFITINIB
Synonyms
JNJ-42756493;CS-2043;Erdafitinib;erdafitnnib;Suftalan Zine;Erdafitinib-d6;Erdafitinib(JNJ-42756493);JNJ-42756493 (Erdafitinib);5-amino-6-fluoropyridine-7-carbonitrile;ERDAFITINIB;JNJ-42756493 ;JNJ 42756493 ;JNJ42756493
CBNumber
CB42725628
Molecular Formula
C25H30N6O2
Formula Weight
446.54
MOL File
1346242-81-6.mol
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ERDAFITINIB Property

Melting point:
136-140°C
Boiling point:
662.3±55.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.45±0.29(Predicted)
color 
Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21813
Product name
JNJ-42756493
Purity
≥98%
Packaging
1mg
Price
$31
Updated
2024/03/01
Cayman Chemical
Product number
21813
Product name
JNJ-42756493
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
21813
Product name
JNJ-42756493
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
21813
Product name
JNJ-42756493
Purity
≥98%
Packaging
25mg
Price
$269
Updated
2024/03/01
TRC
Product number
E594600
Product name
Erdafitinib
Packaging
1mg
Price
$45
Updated
2021/12/16
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ERDAFITINIB Chemical Properties,Usage,Production

Description

Erdafitinib is an oral pan-FGFR (1-4) inhibitor with has demonstrated promising activity in patients with metastatic or unresectable UC and other histologies (eg, cholangiocarcinoma) with FGFR alterations. It is used in the therapy of locally advanced, unresectable or metastatic urothelial carcinoma. Erdafitinib has been associated with a high rate of serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent acute liver injury.

History

In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations, that has progressed during or following platinum-containing chemotherapy, including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. At the same time, the FDA also approved the therascreen FGFR RGQ RT-PCR Kit (Qiagen) for utilization as a companion diagnostic with erdafitinib for selecting patients for the indicated therapy.

Uses

Erdafitinib is a fibroblast growth factor receptor inhibitor.

brand name

Balversa

General Description

Class: receptor tyrosine kinase; Treatment: metastatic urothelial carcinoma; Other name: JNJ-4275693; Elimination half-life = 59 h; Protein binding = 99.8%

target

Primary targets: Pan-FGFR

ERDAFITINIB Preparation Products And Raw materials

Raw materials

Preparation Products

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ERDAFITINIB Suppliers

Canada 1 China 134 India 5 United Kingdom 2 United States 18 Global 160
Chunchuang (Wuhan) Technology Co., Ltd
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View Lastest Price from ERDAFITINIB manufacturers

Apeloa production Co.,Limited
Product
Erdafitinib(JNJ-42756493) 1346242-81-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000
Release date
2024-06-19
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Erdafitinib 1346242-81-6
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-10-14
Shanghai Medfine Bio-pharmaceutical Co., Ltd
Product
Erdafitinib 1346242-81-6
Price
US $0.00/kg
Min. Order
0.001kg
Purity
99%
Supply Ability
kg
Release date
2024-06-07

1346242-81-6, ERDAFITINIBRelated Search:

Panitumumab

  • JNJ-42756493
  • Erdafitinib
  • Erdafitinib(JNJ-42756493)
  • N-(3,5-dimethoxyphenyl)-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine
  • N1-(3,5-Dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine
  • Suftalan Zine
  • N-(3,5-Dimethoxyphenyl)-N'-isopropyl-N-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine
  • N1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine
  • ERDAFITINIB;JNJ-42756493 ;JNJ 42756493 ;JNJ42756493
  • CS-2043
  • JNJ-42756493; JNJ 42756493; JNJ42756493; ERDAFITINIB
  • 1,2-Ethanediamine, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-
  • Erdafitinib-d6
  • JNJ-42756493 (Erdafitinib)
  • 5-amino-6-fluoropyridine-7-carbonitrile
  • erdafitnnib
  • 1346242-81-6
  • API