ChemicalBook > CAS DataBase List > CPI 360

CPI 360

Product Name: CPI 360
CAS No.: 1802175-06-9
Chemical Name: CPI 360
Synonyms: CPI360;CPI-360;CPI 360;CPI-360 (R);CPI360;CPI 360;CPI-360 ，S7656;1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-
CBNumber: CB42729358
Molecular Formula: C25H31N3O4
Formula Weight: 437.53
MOL File: 1802175-06-9.mol

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CPI 360 Property

Boiling point:: 712.2±60.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/mL; DMSO: 25 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH7.2) (1:7): 0.12 mg/mL
form: A crystalline solid
pka: 11.01±0.10(Predicted)
InChIKey: PFPSFENQCNMITC-MRXNPFEDSA-N
SMILES: N1([C@@H](C2CCOCC2)C)C2=C(C=CC=C2)C(C(NCC2=C(OC)C=C(C)NC2=O)=O)=C1C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19125
Product name: CPI-360
Purity: ≥98%
Packaging: 500μg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19125
Product name: CPI-360
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 19125
Product name: CPI-360
Purity: ≥98%
Packaging: 5mg
Price: $231
Updated: 2024/03/01

Cayman Chemical

Product number: 19125
Product name: CPI-360
Purity: ≥98%
Packaging: 10mg
Price: $424
Updated: 2024/03/01

ApexBio Technology

Product number: B4836
Product name: CPI-360
Packaging: 2mg
Price: $167
Updated: 2021/12/16

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CPI 360 Chemical Properties,Usage,Production

Description

CPI-360 is a selective EZH2 inhibitor with IC₅₀ values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively. It decreases cellular levels of H3K27me3 and H3K27me2 (EC₅₀s = 56 and 65 nM, respectively), triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of non-Hodgkin’s lymphoma (NHL) cell lines. Twice daily, subcutaneous administration of 200 mg/kg of CPI-360 reduced tumor growth of KARPAS-422 xenografts in mice.

References

[1] WILLIAM D BRADLEY. EZH2 inhibitor efficacy in non-Hodgkin’s lymphoma does not require suppression of H3K27 monomethylation.[J]. Chemistry & biology, 2014: 1463-1475. DOI: 10.1016/j.chembiol.2014.09.017

CPI 360 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CPI 360 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: CPI-360 1802175-06-9
Price: US $0.00-0.00/mg
Min. Order: 1mg
Purity: 98
Supply Ability: 100G
Release date: 2024-04-17

Career Henan Chemical Co

Product: CPI-360 1802175-06-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1802175-06-9, CPI 360Related Search:

CPI 360

CPI360

CPI-360

CPI360;CPI 360

CPI-360 (R)

1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-

CPI-360 ，S7656

1802175-06-9