CBS9106 (BMS566419)

Product Name: CBS9106 (BMS566419)
CAS No.: 1076235-04-5
Chemical Name: CBS9106 (BMS566419)
Synonyms: SL-801;S-03747;CBS-9106;CBS-9106,CBS9106;Felezonexor，CBS9106;CBS9106 (BMS566419);1-[[6-chloro-5-(trifluoromethyl)pyridin-2-yl]amino]-3-(3,3-dimethylbutoxymethyl)-4-methylpyrrole-2,5-dione;1-((6-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-3-((3,3-dimethylbutoxy)methyl)-4-methyl-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-[(3,3-dimethylbutoxy)methyl]-4-methyl-
CBNumber: CB42731032
Molecular Formula: C18H21ClF3N3O3
Formula Weight: 419.8258496
MOL File: 1076235-04-5.mol

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CBS9106 (BMS566419) Property

form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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CBS9106 (BMS566419) Chemical Properties,Usage,Production

Uses

CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells[1].

in vivo

CBS9106 (31.25-62.5 mg/kg for 5 times weekly, 125 mg/kg for 3 times weekly; p.o.; 2 weeks) significantly suppresses tumor growth at dose levels of 62.5 or 125 mg/kg in mice bearing human MM xenograft models^[1].

Animal Model:	SCID mice with RPMI-8226 cells^[1]
Dosage:	31.25, 62.5, 125 mg/kg
Administration:	Oal administration; 5 times weekly (31.25 and 62.5 mg/kg), 3 times weekly (125 mg/kg); 2 weeks
Result:	Showed statistically significant tumor growth inhibition at dose levels of 62.5 mg/kg or 125 mg/kg.

References

[1] Sakakibara K, et al. CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. Blood. 2011 Oct 6;118(14):3922-31. DOI:10.1182/blood-2011-01-333138

CBS9106 (BMS566419) Preparation Products And Raw materials

Raw materials

Preparation Products

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CBS9106 (BMS566419) Suppliers

China 33 India 1 United States 2 Global 36

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Rechem science Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Kaixin Chemical (Hong Kong) Limited

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
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Changzhou Chenhong Biotechnology Co., Ltd.

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BOC Sciences

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1076235-04-5, CBS9106 (BMS566419)Related Search:

SL-801

1-[[6-chloro-5-(trifluoromethyl)pyridin-2-yl]amino]-3-(3,3-dimethylbutoxymethyl)-4-methylpyrrole-2,5-dione

CBS9106 (BMS566419)

CBS-9106

S-03747

1H-Pyrrole-2,5-dione, 1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-[(3,3-dimethylbutoxy)methyl]-4-methyl-

1-((6-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-3-((3,3-dimethylbutoxy)methyl)-4-methyl-1H-pyrrole-2,5-dione

Felezonexor，CBS9106

CBS-9106,CBS9106

1076235-04-5

C18H21ClF3N3O3

APIs