ChemicalBook > CAS DataBase List > LCH-7749944

LCH-7749944

Product Name
LCH-7749944
CAS No.
796888-12-5
Chemical Name
LCH-7749944
Synonyms
GNF-PF-2356;LCH-7749944;LCH-7749944 ，S1976;LCH-7749944， GNF-PF-2356;LCH-7749944, 10 mM in DMSO;N2-(3-Methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine;2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]-;proliferation,cells,Inhibitor,c-Src,EGFR,inhibit,gastric,Apoptosis,LCH-7749944,PAK,cancer,PAK4,human,LCH7749944,p21 activated kinases,cyclin,LCH 7749944
CBNumber
CB42731092
Molecular Formula
C20H22N4O2
Formula Weight
350.41
MOL File
796888-12-5.mol
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LCH-7749944 Property

Boiling point:
580.0±58.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO: 250 mg/mL (713.45 mM)
pka
7.68±0.30(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0088726
Product name
LCH-7749944
Purity
99.43%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0088726
Product name
LCH-7749944
Purity
99.43%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0088726
Product name
LCH-7749944
Purity
99.43%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0088726
Product name
LCH-7749944
Purity
99.43%
Packaging
100mg
Price
$2250
Updated
2021/12/16
CSNpharm
Product number
CSN25301
Product name
LCH7749944
Packaging
5mg
Price
$80
Updated
2021/12/16
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LCH-7749944 Chemical Properties,Usage,Production

Uses

LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].

IC 50

PAK4: 14.93 μM (IC50)

References

[1] Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317(1):24-32. DOI:10.1016/j.canlet.2011.11.007

LCH-7749944 Preparation Products And Raw materials

Raw materials

Preparation Products

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LCH-7749944 Suppliers

China 32 United States 5 Global 37
Shanghai EFE Biological Technology Co., Ltd.
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796888-12-5, LCH-7749944Related Search:


  • LCH-7749944
  • GNF-PF-2356
  • LCH-7749944， GNF-PF-2356
  • 2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]-
  • N2-(3-Methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine
  • proliferation,cells,Inhibitor,c-Src,EGFR,inhibit,gastric,Apoptosis,LCH-7749944,PAK,cancer,PAK4,human,LCH7749944,p21 activated kinases,cyclin,LCH 7749944
  • LCH-7749944, 10 mM in DMSO
  • LCH-7749944 ，S1976
  • 796888-12-5