Methyl 2-(broMoMethyl)nicotinate
- Product Name
- Methyl 2-(broMoMethyl)nicotinate
- CAS No.
- 116986-08-4
- Chemical Name
- Methyl 2-(broMoMethyl)nicotinate
- Synonyms
- Methyl 2-(broMoMethyl)nicotinate;METHYL 2-(BROMOMETHYL)PYRIDINE-3-CARBOXYLATE;3-Pyridinecarboxylic acid, 2-(broMoMethyl)-, Methyl ester
- CBNumber
- CB42732882
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 116986-08-4.mol
Methyl 2-(broMoMethyl)nicotinate Property
- Boiling point:
- 291.3±30.0 °C(Predicted)
- Density
- 1.533±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.40±0.22(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- M296660
- Product name
- Methyl2-(Bromomethyl)nicotinate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0369169
- Product name
- METHYL-2-(BROMOMETHYL)NICOTINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.71
- Updated
- 2021/12/16
- Product number
- 2763AA
- Product name
- Methyl2-(bromomethyl)nicotinate
- Packaging
- 5g
- Price
- $1670
- Updated
- 2021/12/16
- Product number
- A214108
- Product name
- Methyl2-(bromomethyl)nicotinate
- Purity
- 97%
- Packaging
- 50mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- CD11342568
- Product name
- Methyl2-(bromomethyl)nicotinate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $223
- Updated
- 2021/12/16
Methyl 2-(broMoMethyl)nicotinate Chemical Properties,Usage,Production
Synthesis
65719-09-7
116986-08-4
General procedure for the synthesis of methyl 2-(bromomethyl)nicotinate from methyl 2-methylnicotinate: methyl 2-methylnicotinate (4.1 g, 27.1 mmol), N-bromosuccinimide (NBS, 5.8 g, 32.5 mmol) and azobisisobutyronitrile (AIBN, 100 mg, 0.61 mmol) were dissolved in carbon tetrachloride (55 mL). The reaction mixture was stirred at 90 °C for 16 h under nitrogen protection. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with water (25 mL), followed by extraction of the aqueous layer with dichloromethane (50 mL x 3). The organic layers were combined and concentrated under reduced pressure to remove the solvent, and the resulting crude product was purified by silica gel column chromatography to afford the target product methyl 2-(bromomethyl)nicotinate (5.0 g, 80.6% yield). The product was analyzed by LCMS, m/z: 229.9 ([M+H]+).
References
[1] Patent: WO2015/200677, 2015, A2. Location in patent: Paragraph 00522; 00523
[2] Tetrahedron Letters, 1981, vol. 22, # 50, p. 5097 - 5100
[3] Journal fuer Praktische Chemie (Leipzig), 1987, vol. 329, # 4, p. 557 - 562
[4] Patent: WO2012/61169, 2012, A1. Location in patent: Page/Page column 49
Methyl 2-(broMoMethyl)nicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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